Tag: drug
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 coronavirus infection in vitro
More...We tested the antiviral potential of the antifungal itraconazole and the antidepressant fluoxetine on the production of infectious SARS‐CoV‐2 particles in the polarized Calu‐3 cell culture model and evaluated the added benefit of a combinatory use of these host‐directed drugs with the direct acting antiviral remdesivir, an inhibitor of viral RNA polymerase.
Acriflavine, a clinically aproved drug, inhibits SARS-CoV-2 coronavirus and other betacoronaviruses
We show that acriflavine inhibits viral replication at nanomolar concentration in cellular models, in vivo in mice and ex vivo in human airway epithelia, with broad range activity against SARS-CoV-2 and other betacoronaviruses. More...
Leprosy drug Clofazimine broadly inhibits coronavirus including SARS-CoV-2
Clofazimine, an anti-leprosy drug with a favourable safety profile, possesses pan-coronaviral inhibitory activity, and can antagonize SARS-CoV-2 and MERS-CoV replication in multiple in vitro systems. More...