Category: Remdesivir
Preprint: Mutated SARS-CoV-2 variant resistant to remdesivir
A new preprint study shows that two kidney transplant patients treated with immunosuppressive drugs, and who later had a lengthy COVID-19 infection, developed a version of the virus with a genetic change that made it resistant to the antiviral therapy remdesivir.… ...More...
Research: Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection
“Remdesivir treatment can increase intra-host genomic diversity and result in the emergence of novel major variant species harboring fixed mutations,”.… ...More...
Research: 90% of SARS-CoV-2 viral transmission is cell-to-cell
“The results indicated that around 90 percent of viral transmission was cell-to-cell, possibly via fusion between neighboring infected and uninfected cells.… ...More...
Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 coronavirus infection in vitro
… ...More...We tested the antiviral potential of the antifungal itraconazole and the antidepressant fluoxetine on the production of infectious SARS‐CoV‐2 particles in the polarized Calu‐3 cell culture model and evaluated the added benefit of a combinatory use of these host‐directed drugs with the direct acting antiviral remdesivir, an inhibitor of viral RNA polymerase.
Persistence and Evolution of SARS-CoV-2 in an immunocompromised host
A 154 day Covid infection, with possible multiple different infections.… ...More...
The Alpha variant may have evolved within a chronically-infected individual
The unusual genetic divergence of lineage B.1.1.7 may have resulted, at least in part, from virus evolution with a chronically-infected individual
“What evolutionary processes or selective pressures might have given rise to lineage B.1.1.7?… ...More...
The EU pays more than 1 billion euros for Remdesivir
The European Union has agreed to pay more than 1 billion euros to Gilead for a six-month supply of its antiviral drug remdesivir, shortly before the publication of final results of the biggest trial of the COVID-19 medication.… ...More...