“Hepatitis is common in children with MIS-C and is associated with a more severe presentation and persistent elevation of LFTs in many.”
“This is a retrospective cohort study of 44 patients with MIS-C admitted at Morgan Stanley Children’s Hospital of New York-Presbyterian during April and May 2020. We evaluated the number of patients who developed hepatitis and examined both demographics and inflammatory laboratory values to ascertain those that were at higher risk for liver involvement and more severe disease. Hepatitis was present in 19 subjects (43%) and was associated with more severe disease.
Hepatitis is common in children with MIS-C and is associated with a more severe presentation and persistent elevation of LFTs in many. Despite the positive outcomes reported here, close follow-up is warranted given the limited knowledge of the long-term impact of SARS-CoV-2 on the liver.”
A newly recognized Multisystem Inflammatory Syndrome in Children (MIS-C) has had a paradigm-shifting effect on the perception of SARS-CoV-2 illness severity in children. We report the clinical and biochemical features of liver involvement, and the comorbidities that present with hepatitis, in a substantial cohort of patients.
A detailed 🧵 on the alarming rise in cases of acute liver failure in healthy children:
Media + scientific bodies have placed undue emphasis on Adenovirus infection as the leading culprit in such cases of liver failure.
Let us see if this claim holds water [short answer: No!]
— Farid Jalali MD (@farid__jalali) April 30, 2022
Wow it’s even worse than I realized… Not only did they NOT check for prior/recent covid infection, they didn’t even check the livers for covid. “No immunohistochemical evidence of adenovirus.”
— Dr. Lisa Iannattone (@lisa_iannattone) April 29, 2022
— Corona Heads Up (@CoronaHeadsUp) April 29, 2022
So it’s pure coincidence that cases of hepatitis in children are cropping up across the globe during a global pandemic of a virus that is known to cause hepatitis?