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Preprint: Bergamottin exhibits inhibitory activity against SARS-CoV-2

Coronavirus, Health, Healthcare, Preprint, Research, Treatment

Here, we reported that bergamottin, a furanocoumarin originally found in bergamot, exhibited inhibitory activity against SARS-CoV-2 in vitro, ex vivo, and in vivo.

Bergamottin interfered with multiple stages of virus life cycles, specifically blocking the SARS-CoV-2 spike-mediated membrane fusion and effectively reducing viral RNA synthesis. Oral delivery of bergamottin to golden Syrian hamsters at dosages of both 50 mg/kg and 75 mg/kg reduced the SARS-CoV-2 load in nasal turbinates and lung tissues. Pathological damage caused by viral infection was also ameliorated after bergamottin treatment.

Highlights:

  • Bergamottin inhibits the infection of wild type SARS-CoV-2, Alpha (B.1.1.7), and Beta (B.1.351).
  • Bergamottin inhibits SARS-CoV-2 infection on both entry and replication steps.
  • Oral administration of bergamottin reduces the SARS-CoV-2 load in nasal turbinates and lung tissues in golden Syrian hamsters.

Preprint: Bergamottin, a bioactive component of bergamot, inhibits SARS-CoV-2 infection in golden Syrian hamsters

 

 

 

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