Category: Preprint
SARS-CoV-2 may infect bacteria in the gut, act as a bacteriophage
“SARS-CoV-2 could .. infect bacteria in the gut microbiota, indicating that SARS-CoV-2 could act as a bacteriophage”
“Our recent studies show that microorganisms in the human gastrointestinal tract affect the severity of COVID-19 and for the first time provide indications that the virus might replicate in gut bacteria.… ...More...
10% risk of being infected with Covid-19 in public toilets
A Thai study has found that, without facemasks, there was a 10% risk of being infected with Covid-19 in public toilets, but the risk increased to almost 100% if the Covid-19 infected person coughed or sneezed in the toilet. … ...More...
BMJ: One hour longer sleep at night associated with 12% lower odds of COVID-19
“Among 2884 exposed HCWs, there were 568 COVID-19 cases and 2316 controls. After adjusting for confounders, 1-hour longer sleep duration at night was associated with 12% lower odds of COVID-19 (p=0.003).… ...More...
Preprint: L452R mutation increases Omicron variant fusogenicity and infectivity
Here, we developed an L452R mutated Omicron variant (Omicron-L452R) and found that the Omicron-L452R variant rescued fusogenicity and strengthened the high infectivity by enhancing the cleavage of the spike protein.… ...More...
Preprint: 100% symptomatic infection with XD recombinant
“This recombinant (XD) exhibits immune escape properties similar to Omicron, while its behavior in mice expressing the human ACE2 receptor is more similar to Delta.”… ...More...
Preprint: Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage
We hypothesize that SARS-CoV-2 spike (S) protein is sufficient to cause olfactory damage and olfactory dysfunction.
Using an adult zebrafish model, we report that intranasally delivered SARS-CoV-2 S RBD mostly binds to the non-sensory epithelium of the olfactory organ and causes severe olfactory histopathology characterized by loss of cilia, hemorrhages and edema.… ...More...
Preprint: Multi-organ impairment and Long COVID
“3 in 5 people with Long COVID have impairment in at least one organ, and 1 in 4 have impairment in two or more organs, in some cases without symptoms.”… ...More...
Preprint: SARS-CoV-2 Omicron – multiple inter-variant recombination events
“By analyzing sequences from a large number of Omicron subvariants, we identified diverse recombination events between two Omicron subvariants and several SARS-CoV-2 variants, suggesting that co-infection and subsequent genome recombination play important roles in the on-going evolution of SARS-CoV-2.… ...More...
Preprint: Intracellular Reverse Transcription into DNA of mRNA Vaccine
We show that BNT162b2 mRNA is reverse transcribed intracellularly into DNA in as fast as 6 hours upon BNT162b2 exposure.… ...More...