UK: #coronavirus vaccine breakthrough cases reported with B.1.351 and B.1.1.7 variants

People in the UK have been infected with Covid-19 more than once thanks to catching different variants of the coronavirus. Dr Susan Hopkins, chief medical adviser for NHS Test and Trace, said there had been cases where people had become reinfected by different strains of the coronavirus. “We have seen some people who have had their first dose of vaccine who have had the South African variant and the variant that arose in Kent,” she told BBC’s the Andrew Marr show. “You can see that they’re not as good against the South African variant as they are against our own (variant) B117 at preventing infection and transmission.” report



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UK: Indian “Double Mutant” coronavirus variant B.1.617 “could be a lot more problematic than the South African and Brazilian variants”

Prof Paul Hunter, professor in medicine at the University of East Anglia, told the Guardian that the arrival of the India variant was potentially worrying. He said: “These two escape mutations working together could be a lot more problematic than the South African and Brazilian variants which have only got one escape mutation. “It might be even less controlled by vaccine than the Brazilian and South African variants.”

The variant featured two “escape mutations” – E484Q and L452R – that “are causing people to be concerned. “There’s laboratory evidence that both of these are escape mutations. Basically, applying what we know about other human coronaviruses would suggest that this is going to be even less controlled by vaccine. But we don’t know that for certain at the moment”

The Guardian report


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USA: CDC reports 5,800 COVID-19 vaccine breakthrough infections in fully vaccinated Americans, 74 deaths

About 5,800 Americans who have been vaccinated against coronavirus have become infected anyway, the U.S. Centers for Disease Control and Prevention tells CNN. Some became seriously ill and 74 people died, the CDC said. It said 396 — 7% — of those who got infected after they were vaccinated required hospitalization.

It’s the first indication from CDC of how effective the vaccine is in real life — and the first indication the vaccines do not protect completely against severe disease and death. report



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Louisiana: 170 #coronavirus vaccine breakthrough cases reported

As of Thursday (April 8), 170 people in Louisiana were classified as having a “breakthrough” vaccine COVID case – testing positive for coronavirus after being fully vaccinated. A week earlier, the state reported 126 cases. The health department released new data Thursday during a news conference after WBRZ made repeated requests for information. report


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Rhode Island: 290 #coronavirus vaccine breakthrough cases reported, three dead and 20 hospitalized

Nearly 300 Rhode Islanders have tested positive for COVID-19 after being vaccinated against the virus — a total that state public-health officials consider a positive sign of the vaccines’ effectiveness.  Three of the state’s 290 post-vaccination positive cases died and 20 were hospitalized, the state Department of Health said Tuesday.

The 290 “breakthrough” infections, as post-vaccine cases are known, came out of 212,060 people who received their final shot 14 days ago, representing about 0.13% of that group. 

Providence Journal report


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Denmark: 29 claims for compensation made for side-effects following AstraZeneca #coronavirus vaccination

Denmark has received the first claim for compensation for a death caused by a special type of blood clot, which the authorities link with the Astrazeneca vaccine. The patient compensation scheme has received a total of 29 compensation applications from citizens who have received the Astrazeneca vaccine. A further eight cases concern the Pfizer vaccine. There are no claims for Moderna.

This is stated by Patienterstatningen, which handles cases of compensation for citizens who are affected by serious side effects from e.g. medicines.

“We know there are more cases out there and we would like to have them in” said Karen-Inger Bast, Director of Patient Compensation.

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Mississippi: 78 cases of vaccine breakthrough reported

The Mississippi State Department of Health is reporting 78 breakthrough cases of COVID-19. Of those 78 breakthrough cases, one individual died of COVID-19.

“That’s one of the things that we’re following, is to look at who is being impacted with breakthrough COVID after they’ve been fully vaccinated,” said state epidemiologist Dr. Paul Byers.

State health leaders said there are 635,000 fully vaccinated Mississippians and the number of breakthrough cases is comparatively low. They said that’s proof the vaccines are working. report


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Alaska: 177 #coronavirus vaccine breakthrough cases reported

Of the 177 breakthrough infections in Alaska as of this week, one person has required hospitalization and no one has died, according to Bennett. State health officials this week said a majority of breakthrough cases were asymptomatic.

Anchorage Daily News report


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Glucocorticoids and B Cell Depleting Agents substantially impair immunogenicity of mRNA vaccines to SARS-CoV-2 #coronavirus

Compared to immunocompetent controls, a three-fold reduction in anti-S IgG titers (P=0.009) and SARS-CoV-2 neutralization (p<0.0001) were observed in CID patients. B cell depletion and glucocorticoids exerted the strongest effect with a 36- and 10-fold reduction in humoral responses, respectively (p<0.0001). Janus kinase inhibitors and antimetabolites, including methotrexate, also blunted antibody titers in multivariate regression analysis (P<0.0001, P=0.0023, respectively). Other targeted therapies, such as TNF inhibitors, IL-12/23 inhibitors, and integrin inhibitors, had only modest impacts on antibody formation and neutralization.

Conclusions CID patients treated with immunosuppressive therapies exhibit impaired SARS-CoV-2 vaccine-induced immunity, with glucocorticoids and B cell depletion therapy more severely impeding optimal responses.

Medrxiv Preprint



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Illinois: Nearly 600 #coronavirus vaccine breakthrough cases reported

More than 580 Illinoisans have tested positive for COVID-19 despite being fully vaccinated. The Illinois Department of Public Health reported that of the about 2.5 million people in Illinois who have been fully vaccinated, as of data compiled Wednesday, 581 tested positive for COVID-19 after getting their final vaccine dose.

“We’re looking to report breakthrough data once a week, but are waiting for more information from the [Centers for Disease Control and Prevention],” a spokesman for the Illinois Department of Public Health said Monday. report


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CDC: Moderna’s COVID-19 #coronavirus vaccine could lead to more side effects than Pfizer/BioNTech’s

New research from the U.S. Centers for Disease Control and Prevention suggests that people who receive Moderna’s COVID-19 vaccine might experience more side effects than those who get Pfizer/BioNTech’s vaccine. The agency’s findings come from a study published in the online journal JAMA. The data revealed that 75% of Moderna recipients reported side effects after getting one dose of the COVID-19 vaccine compared to 65% of the Pfizer/BioNTech recipients. Side effects included pain at the injection site, fatigue and headaches. report

Jama preprint


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North Dakota: 103 #coronavirus vaccine breakthrough cases reported

So far, there have been 103 vaccine breakthrough cases in North Dakota. Of those, six people were hospitalized. State health experts say their symptoms varied.

“We have some people that are completely asymptomatic. We do have some people that are quite a bit sicker. It still kind of depends on the age of the person, the underlying health conditions. All that stuff that kind of affects your COVID outcomes, still affects you the same even after you’ve been vaccinated,” said North Dakota Department of Health Immunization Surveillance Coordinator Jenny Galbraith.



Minnesota: 222 #coronavirus vaccine breakthrough cases reported

“While the NBC News affiliate reported that more than 1.8 million Minnesotans have received at least one vaccine dose, as of April 2, the state’s Department of Health has reported 222 vaccine breakthrough cases.” report


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Washington State: 102 #coronavirus vaccine breakthrough cases reported, 8 hospitalizations, 2 deaths

Out of one million fully vaccinated individuals in Washington state, epidemiologists report evidence of 102 breakthrough cases since February 1, 2021, which represents .01 percent of vaccinated people in Washington.

Breakthrough cases have been identified in 18 counties. The majority of those in Washington state with confirmed vaccine breakthrough experienced only mild symptoms, if any. However, since February 1, eight people with vaccine breakthrough have been hospitalized. DOH is investigating two potential vaccine breakthrough cases where the patients died. Both patients were more than 80 years old and suffered underlying health issues. report



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