Preprint: 75% of Covid ICU patients report symptoms after one year

Of 246 patients who were alive 1 year following ICU treatment for COVID-19, 74.3% reported physical symptoms, 26.2% reported mental symptoms, and 16.2% reported cognitive symptoms.

Physical, mental, and cognitive symptoms were frequent 1 year after ICU treatment for COVID-19.

Jama Network Preprint: Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19

 

 

 

 

 

Image by Okan Caliskan from Pixabay

Science Magazine: Covid vaccines may cause Long Covid–like symptoms

In November 2021, in the New England Journal of Medicine, William Murphy, an immunologist at the University of California, Davis proposed that an autoimmune mechanism triggered by the SARS-CoV-2 spike protein might explain both Long Covid symptoms and some rare vaccine side effects.

Evidence from animal studies supports the idea that antibodies targeting the SARS-CoV-2 spike protein might cause collateral damage, notes Harald Prüss, a neurologist at the German Center for Neurodegenerative Diseases (DZNE) and the Charité University Hospital in Berlin. In 2020, while hunting for antibody therapies for COVID-19, he and his colleagues discovered that of 18 antibodies they identified with potent effects against SARS-CoV-2, four also targeted healthy tissues in mice—a sign they could trigger autoimmune problems.

Science Magazine article

New England Journal of Medicine article:A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination

Harald Prüss: Do cross-reactive antibodies cause neuropathology in COVID-19?

 

 

 

Image by Engin Akyurt from Pixabay

COVID-19 patients show more signs of brain damage than Alzheimer’s sufferers

Patients hospitalized for COVID-19 had higher levels over the short term of blood proteins known to rise with neurological damage than non–COVID-19 patients diagnosed with Alzheimer’s disease, a new study finds.

Study authors found the markers for brain damage were even worse among patients that did not survive their coronavirus infection. Markers among patients who died from COVID were 124 percent higher than those who eventually left the hospital.

Nyulangone.org article

Serum neuronal, glial, and axonal neurodegenerative biomarkers, including t-tau, p-tau181, UCHL1, GFAP, and NfL were significantly elevated in patients with encephalopathy and worse discharge disposition after hospitalization for COVID-19. These markers correlated with the severity of COVID illness. Furthermore, levels of NfL, GFAP, and UCHL1 in hospitalized COVID patients were similar to, or higher than, levels observed in non-COVID AD dementia patients. Additional studies tracking trajectories of these biomarkers over time and their association with long-term cognitive outcomes among COVID-19 survivors are warranted.

Alzheimers Association Study – Comparison of serum neurodegenerative biomarkers among hospitalized COVID-19 patients versus non-COVID subjects with normal cognition, mild cognitive impairment, or Alzheimer’s dementia

 

See also: January 2022 Preprint – Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

 

 

Sars-CoV-2 filmed attacking the brain of a bat

 

 

 

Photo by jesse orrico on Unsplash

Long COVID in 2009: Mental Morbidities and Chronic Fatigue in SARS Survivors

From 2009, Long COVID in SARS survivors:   Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, and 27.1% met the modified 1994 Centers for Disease Control and Prevention criteria for chronic fatigue syndrome. 

Results Of 369 SARS survivors, 233 (63.1%) participated in the study (mean period of time after SARS, 41.3 months). Over 40% of the respondents had active psychiatric illnesses, 40.3% reported a chronic fatigue problem, and 27.1% met the modified 1994 Centers for Disease Control and Prevention criteria for chronic fatigue syndrome.

Logistic regression analysis suggested that being a health care worker at the time of SARS infection (odds ratio [OR], 3.24; 95% confidence interval [CI], 1.12- 9.39; P = .03), being unemployed at follow-up (OR, 4.71; 95% CI, 1.50-14.78; P = .008), having a perception of social stigmatization (OR, 3.03; 95% CI, 1.20-7.60; P = .02), and having applied to the SARS survivors’ fund (OR, 2.92; 95% CI, 1.18-7.22; P = .02) were associated with an increased risk of psychiatric morbidities at follow-up, whereas application to the SARS survivors’ fund (OR, 2.64; 95% CI, 1.07-6.51; P = .04) was associated with increased risk of chronic fatigue problems.

Jama Network paper: Mental Morbidities and Chronic Fatigue in Severe Acute Respiratory Syndrome Survivors

 

Finland: 50% of infected adults have long COVID

 

 

 

Photo by jet dela cruz on Unsplash

Finland: 50% of infected adults have long COVID

Long COVID could become one of Finland’s largest groups of chronic diseases, according to a Finnish government Minister.

Long COVID, where symptoms of COVID-19 persist for months after an initial infection, could be emerging as a chronic disease in Finland, Minister of Family Affairs and Social Services Krista Kiuru said on 7th January 2022.

Speaking at a news conference, she referred to a Finnish expert panel’s summary of more than 4,000 international studies which showed one in two adults and around 2 per cent of children may experience prolonged symptoms connected to COVID-19.

“There is a threat that Finland will see the emergence of the largest, or one of the largest, new groups of chronic diseases, and that not only adults will suffer from a long-term COVID-19, but also children,” Kiuru said.

The Finnish institute of health and welfare considers an illness chronic when it has a major impact on public health and the national economy through lowered working capacity and strains on healthcare.

The summary published by the Ministry of Social Affairs and Health said long COVID was more likely when the initial infection had required hospitalisation, but it might also occur after a mild or asymptomatic infection.

“The virus has been shown to enter the brain through the nose and its effects are also seen on magnetic resonance imaging,” Risto Roine, professor of neurology and chairman of the expert panel, told the same news conference.

“Around 20 per cent see long-term cognitive impairment,” Roine added, warning that the incidence of neurological diseases such as Alzheimer’s or Parkinson’s could increase sharply following a COVID-19 infection.

The Nordic nation of 5.5 million people recorded nearly 10,000 new coronavirus cases on Friday, bringing its tally since the pandemic began to 305,522. Six deaths brought the total in Finland to 1,638

CNA News Report 

 

Finland long COVID Press conference (in Finnish):

 

Finland’s current daily Covid case rates are currently TEN TIMES as high as its previous record set August 2021

 

Covid-19 is a global squid game. There are only two rules to the game:
1) Don’t die of the virus
2) Don’t become infected with the virus

Will the UK’s mass Covid infection experiment pay off?

 

Long COVID in 2009: Mental Morbidities and Chronic Fatigue in SARS Survivors

 

 

Image by Oleg Mityukhin from Pixabay

UK ONS: 1.3 million long COVID cases in Britain – 2% of the population

ONS: An estimated 1.3 million people living in private households in the UK were experiencing self-reported long COVID as of 6 December 2021. That represents 2.0% of the population.

An estimated 1.3 million people living in private households in the UK (2.0% of the population) were experiencing self-reported long COVID (symptoms persisting for more than four weeks after the first suspected coronavirus (COVID-19) infection that were not explained by something else) as of 6 December 2021.

The proportion of people with self-reported long COVID who reported that it reduced their ability to carry out daily activities remained stable compared with previous months; symptoms adversely affected the day-to-day activities of 809,000 people (64% of those with self-reported long COVID), with 247,000 (20%) reporting that their ability to undertake their day-to-day activities had been “limited a lot”.

Fatigue continued to be the most common symptom reported as part of individuals’ experience of long COVID (51% of those with self-reported long COVID), followed by loss of smell (37%), shortness of breath (36%), and difficulty concentrating (28%).

As a proportion of the UK population, prevalence of self-reported long COVID was greatest in people aged 35 to 69 years, females, people living in more deprived areas, those working in health care, social care, or teaching and education (which saw the biggest month-on-month increase out of all employment sectors), and those with another activity-limiting health condition or disability.

ONS: Prevalence of ongoing symptoms following coronavirus (COVID-19) infection in the UK : 6 January 2022

 

Boris Johnson: We can ‘ride out’ the Omicron wave with no more curbs

 

Image by Engin Akyurt from Pixabay

Boris Johnson: We can ‘ride out’ the Omicron wave with no more curbs

London, 1940. The city is being heavily bombed in the Blitz. Hundreds of civilians are dying daily. Prime Minister Boris Johnson has taken to the airwaves to reassure the public, and to urge them to go outside and enjoy the bombing.

Johnson’s Conservative party are staunchly against any further blackouts being imposed. Pubs, cinemas and theatres remain open, football stadiums are packed, and planes are still flying. Business, it seems, must go on, even at the expense of large loss of life and serious injury.  No one gives a hoot, least of all the clearly deranged Prime Minister or his supine, boot-licking cabinet.

WW2 – “Londoners take to shelters”

 

BBC: Boris Johnson plans to ‘ride out’ Omicron wave with no more curbs

 

** The number of casualties of the Covid-19 pandemic in Britain already far outweighs those killed in the Blitz. In the eight months of Blitz attacks, some 43,000 civilians were killed. This amounted to nearly half of Britain’s total civilian deaths for the whole war.

 

UK Covid case rates have been running at astronomical levels since “Freedom Day” was announced in July 2021:

 

UK ONS: 1.3 million long COVID cases in Britain – 2% of the population

It’s the largest global Covid wave EVER

Driven by the new Omicron variant, the world is now being overwhelmed by the largest global Sars-CoV-2 wave EVER. The current winter wave is now larger than the Indian wave in spring 2021, and has also easily exceeded last winter’s global wave by some margin.

The word’s largest ever Covid wave is being driven by new cases in North America and Europe, just as the last winter wave of 2020-2021 was.

Unfortunately, just as the global media celebrates the new “milder” Omicron variant, the likely consequences of the emergence of the variant are being completely overlooked.

A simple extrapolation of the events of the last two years would suggest that the next Covid release could be the first ever Variant of High Consequence or VOHC.

A VOHC would be far more transmissible than Omicron, far more deadly than Delta, and it could be in circulation within weeks.

It is patently obvious that, even after two years of this pandemic, the world is COMPLETELY unprepared for what is coming.

 

The 2021 winter wave will be the largest Covid wave so far

3 billion Omicron infections worldwide predicted

A report from the University of Washington’s Institute for Health Metrics and Evaluation is predicting 3 billion new infections of the Omicron variant worldwide over the next two months. That’s as many infections the world has seen since the COVID-19 pandemic first began, according to the IHME.

When compared to the Delta variant, IHME researchers believe there will be fewer hospitalizations and deaths overall. However, with so many people infected in such a short amount of time, hospitals could still become overwhelmed.

Kiro7.com report



Long Covid, as usual, doesn’t get a mention in the report, however,

If you apply a 30% Long Covid rate to 3 billion people, 900 million people worldwide would be affected

If you apply a 40% Long Covid rate to 3 billion people, 1.2 billion people worldwide would be affected

If you apply a 50% Long Covid rate to 3 billion people, 1.5 billion people worldwide would be affected



Headsup:  Omicron is a proof-of-concept attack. As with any computer virus on your network, Omicron is showing what the coronavirus is capable of. In this case, it has just shown it can circumvent the vaccines with ease.
The virus can now combine that immune evasion ability with whatever else it has in its arsenal – greater lethality, greater morbidity, targeted lines of attack, new hosts etc. Extinct variants could re-emerge with a protective shield against vaccines. The possibilities are endless.
Omicron is a viral can opener, and  it has just opened up a whole new can of worms for humanity.
Please do not be fooled by the “mild” tag now being used across the mainstream media. The arrival of Omicron is not a cause for celebration. It is, without doubt, the worst turn of events in the pandemic since Sars-CoV-2 originally appeared in Wuhan.
Omikron is a back door root virus that will allow far worse variants to infect, main and kill humans.

 

Germany: 40 percent suffer from Long Covid after infection

 

 

 

 

 

 

 

Image by Keith Johnston from Pixabay

London ablaze with Covid: Brixton has 4,445 Covid cases per 100,000 people

Central and south London are ablaze with Covid. Most areas of London have a case rate of over 1,600 per 100,000 people, and in Brixton, south London, the case rate is an astonishing 4,445 per 100,000 people. That is by far the highest case rate we have seen in the entire pandemic.

 

 

Boris Johnson has just ruled out extra measures to contain the spread of the disease.

Boris has now left the building – presumably for somewhere a lot safer than central London

 

 

 

Source: Interactive maps from UK.gov

 

 

Preprint: Brain imaging before and after Covid in UK Biobank

We identified .. a more pronounced reduction in grey matter thickness, and … a greater reduction in global measures of brain size and increase in cerebrospinal fluid volume.

“we identified respectively 68 and 67 significant longitudinal effects associated with SARS-CoV-2 infection in the brain, including, on average: (i) a more pronounced reduction in grey matter thickness and contrast in the lateral orbitofrontal cortex (min P=1.7×10 -4 , r=-0.14) and parahippocampal gyrus (min P=2.7×10 -4 , r=-0.13), (ii) a relative increase of diffusion indices, a marker of tissue damage, in the regions of the brain functionally-connected to the piriform cortex, anterior olfactory nucleus and olfactory tubercle (min P=2.2×10 -5 , r=0.16), and (iii) greater reduction in global measures of brain size and increase in cerebrospinal fluid volume suggesting an additional diffuse atrophy in the infected participants (min P=4.0×10 -6 , r=-0.17). When looking over the entire cortical surface, these grey matter thickness results covered the parahippocampal gyrus and the lateral orbitofrontal cortex, and extended to the anterior insula and anterior cingulate cortex, supramarginal gyrus and temporal pole. The increase of a diffusion index (mean diffusivity) meanwhile could be seen voxel-wise mainly in the medial and lateral orbitofrontal cortex, the anterior insula, the anterior cingulate cortex and the amygdala”

Preprint: Brain imaging before and after COVID-19 in UK Biobank

 

 

Image by VSRao from Pixabay

Preprint: Internal tremors and vibration symptoms among people with Long Covid

“Sometimes my entire body feels like it’s humming and trembling. It’s like I’m sitting on a huge speaker with the volume all the way up.”

“Internal vibrations started about 3 weeks after. They started in my back and back of upper thighs. It felt like I was sitting on a vibration massage chair. They never went away but would vary in intensity. February 2021 I started having restless left arm at bedtime where my left arm would flap until I fell asleep. On [May 2021] it progressed to full body myoclonic movements lasting up to 30 minutes.”

“My brain shakes after a few hours inside my head, my face starts to tingle and numb, and then the full head shaking seizures start. I have severe head pain and nausea constantly from all the seizures.”

“That week of unrelieved spasms left my body barely able to move. Like paralyzed. I had 3 natural child births. I could not fake such 10/10 pain. I have never felt such intense pain, I thought my back would break and my right arm would be completely dislocated twisted out of socket. I could not breathe at times due to the Laryngeal spasms and diaphragm spasms.”

Medrxiv Preprint: Internal Tremors and Vibration Symptoms Among People with Post-Acute Sequelae of SARS-CoV-2: A narrative review of patient reports

 

“She [Ferrer] said it was like somebody inserting a cell phone into your chest and turning off the vibration function, but they have the ability to turn it on randomly at any point in the night,”.

Salon.com – Tremors and “internal vibrations”: Long Covid patients are reporting Parkinson’s-like symptoms

 

What is in your vaccine? German researchers analyze Pfizer & AstraZeneca vaccines to find out

 

Image by Gerd Altmann from Pixabay

Covid causes brain damage, even in mild cases

“We’re following about 700 patients here at McGovern. We’ve looked and found dramatic increases in brain injury markers in the blood of people with Covid,” said Dr. McCullough, MD, PhD, chair of Neurology at UTHealth.

An alarming study done in the UK has found something similar.

Researchers had brain scans from over 700 patients, which were done before the pandemic. They did second MRI’s around three years after the first scan. 394 patients between 59 and 63 years old got the virus between the two scan. Those who recovered from COVID-19 had more brain atrophy or shrinkage in parts of the brain that control taste, smell, and memory. Most of those COVID cases were mild.

“Is it going to increase Alzheimer’s rates, dementia rates – even in people who are only mildly affected? This is something that could be a major public health crisis 20 years from now,” said Dr. McCullough “The next step is seeing, do the patients who have the worst brain shrinkage or volume loss have the worse memory?”

Khou.com article

 

Italy: Up to 70% of patients with moderate to severe Covid-19 report neurological symptoms 6 months later

 

Long Covid: Cognitive impairment and psychiatric symptoms may affect up to 76% of patients

 

Photo by Fakurian Design™ on Unsplash

Long Covid: Cognitive impairment and psychiatric symptoms may affect up to 76% of patients

A considerable proportion of patients, up to 84% of those with severe COVID-19, show neurological signs and symptoms including anosmia, epileptic seizures, strokes, loss of consciousness and confusion

Beyond 4 weeks after onset, the post-acute COVID-19 syndrome includes cognitive impairment and a range of psychiatric symptoms and may affect up to 76% of patients

Although a direct infection of the brain remains a matter of debate, SARS-CoV-2 viral genomes were detected in the brain and cerebrospinal fluid (CSF) of some patients, supporting the notion that SARS-CoV-2 gains access to the brain

Preprint: The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

 

 

 

Image by Manfred Richter from Pixabay