USA: SARS-CoV-2 Delta variant spillover from human to horse

“A report on a possible direct exposure to SARS-CoV-2 from a COVID-19-positive individual to an adult horse.”

The individual, diagnosed with COVID-19 (Delta B.1.617.2), had daily contact to her two horses prior to and during the development of clinical disease....More...

Preprint: SARS-CoV-2 infects the entire genital tract

“A robust signal was seen in the male genital tract (MGT) of all three animals studied. Infection of the MGT was validated by immunofluorescence imaging of infected cells in the testicular and penile tissue and severe pathology was observed in the testes of one animal at 2-weeks post-infection.”...More...

France: B.1.160 outbreak may have begun in mink

“based on genomic, geographical and temporal coincidences, that the source of the Marseille-4 (B.1.160) epidemic was the mink”.

The Marseille-4 variant (B.1.160) was the most prevalent SARS-CoV-2 variant in our geographical area in 2020 and was only outdone by the Alpha (UK, B.1.1.7) variant in 2021....More...

Preprint: Omicron BA.1 infection in mink leads to symptomatic disease with lung pathology and transmission

Experimental infection of American mink with SARS-CoV-2 Omicron variant BA.1 show that minks remain virus RNA positive for days, develop clinical signs and histopathological changes, and transmit the virus to uninfected recipient....More...

Preprint: SARS-CoV-2 infects and replicates in human testes

“The virus remains infective after a long infection period in the testes (viral reservoir)”

This is the first study that shows:
1) the high SARS-CoV-2 tropism to the testis
2) one mode of SARS-CoV-2 entrance in testes
3) SARS-CoV-2 preferred infection and replication in spermatogonia and macrophages
4) that the virus remains infective after a long infection period in the testes (viral reservoir)
5) high levels of angiotensin II and activated mast cells and macrophages are critical players in promoting all testicular alterations
6) the more extended severe condition, the lower the number of surviving germ cells
7) fluctuation in several essential testicular genes
8) that the intratesticular testosterone levels are 30 times reduced in testes of COVID-19 patients
9) the prevalent types of collagen present in SARS-CoV-2 mediated testicular fibrosis
10) the fluctuation of vasoconstrictive peptides in testes of COVID-19 critically ill patients

Medrxiv Preprint: SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes

 

Sars-CoV-2 – checkmate to the virus in four moves

 

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USA: Omicron in white-tailed deer on Staten Island, New York *1 UPDATE*

White-tailed deer on Staten Island have become the first wild animals with documented Omicron infections.

The researchers also found that one deer with Omicron already had a high level of antibodies to the virus, suggesting that it may have been previously infected....More...