NEJM: In two #coronavirus vaccine breakthrough cases “examination of the SARS-CoV-2 sequences revealed that both patients were infected with variant viruses” .. “neither sequence precisely fit any known clade”

Examination of the SARS-CoV-2 sequences revealed that both patients were infected with variant viruses. Rapid identification of sequence variants by targeted PCR amplification showed that neither sequence precisely fit any known clade. Some of the substitutions in Patient 1 (T95I, del144, E484K, A570D, D614G, P681H, and D796H) were shared with B.1.526 (T95I, E484K, and D614G6), and three substitutions were shared with Patient 2 (in whom the variants T95I, G142V and del144, F220I, R190T, R237K, R246T, and D614G were detected).

NEJM article  “Vaccine Breakthrough Infections with SARS-CoV-2 Variants”

 

Image by Daniel Roberts from Pixabay

Event 201 – A pandemic exercise hosted by Johns Hopkins Center for Health Security, the World Economic Forum and the Bill and Melinda Gates Foundation on October 18, 2019, in New York, NY

Event 201 is a pandemic tabletop exercise hosted by The Johns Hopkins Center for Health Security in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation on October 18, 2019, in New York, NY

New #Coronavirus Variant #B1526 is spreading in New York City

A new form of the coronavirus is spreading rapidly in New York City, and it carries a worrisome mutation that may weaken the effectiveness of vaccines, two teams of researchers have found.

The new variant, called B.1.526, first appeared in samples collected in the city in November. By the middle of this month, it accounted for about one in four viral sequences appearing in a database shared by scientists.

One study of the new variant, led by a group at Caltech, was posted online on Tuesday. The other, by researchers at Columbia University, was published on Thursday morning.

New York Times Report

Caltech paper

Columbia University paper

 

Image by Alexandra_Koch from Pixabay

New York City #NYC public schools halt in-person classes as #COVID19 crisis deepens

New York City’s school district, the largest in the United States, will halt in-person learning starting on Thursday, Mayor Bill de Blasio announced, the latest major restriction as the nation’s COVID-19 infections soar.

“New York City has reached the 3% testing positivity 7-day average threshold. Unfortunately, this means public school buildings will be closed as of tomorrow, Thursday Nov. 19, out [of] an abundance of caution,” de Blasio wrote on Twitter. “We must fight back the second wave of COVID-19.”

https://uk.reuters.com/article/idUKKBN27Y2M1

 

 

Image by Free-Photos from Pixabay

#NYC schools could close if #coronavirus positivity rate hits 3%

Facing a second wave of the coronavirus, New York City stands on the precipice of once again closing its classrooms. On Friday, Mayor Bill de Blasio warned that the public school system could close as early as Monday as the citywide seven-day average rate of positive test results increased to 2.83 percent. He has committed to closing the system if the rate reaches 3 percent.

Parents “should have an alternative plan beginning as early as Monday,” Mr. de Blasio said on “The Brian Lehrer Show” on WNYC.

https://www.nytimes.com/live/2020/11/13/world/covid-19-coronavirus-updates#nycs-mayor-warns-that-public-schools-could-close-as-early-as-monday-if-positivity-rate-hits-3-percent

Image by Free-Photos from Pixabay

New York Times survey of more than 1,700 American colleges and universities reveals more than 252,000 #coronavirus cases and at least 80 deaths since the pandemic began

Thousands of new coronavirus cases continue to emerge on college campuses. A New York Times survey of more than 1,700 American colleges and universities — including every four-year public institution and every private college that competes in N.C.A.A. sports — has revealed more than 252,000 cases and at least 80 deaths since the pandemic began.

Most of the cases have been announced since students returned to campus for the fall term. Most of the deaths were reported in the spring and involved college employees, not students.

But at least three students — Jamain Stephens, a football player at California University of Pennsylvania; Chad Dorrill, a sophomore at Appalachian State; and Bethany Nesbitt, a student at Grace College — have died in recent weeks after contracting the virus.

https://www.nytimes.com/interactive/2020/us/covid-college-cases-tracker.html