Preprint: MU B.1.621 the most resistant variant to convalescent and vaccinated sera to date

America, Argentina, B.1.621, Chile, Colombia, Coronavirus, Infection, MU, Peru, Pfizer/Biontech, Sinovac, Vaccine, Vaccine Breakthrough, Variants

Here, we demonstrate that the Mu variant is highly resistant to sera from COVID-19 convalescents and BNT162b2-vaccinated individuals. Direct comparison of different SARS-CoV-2 spike proteins revealed that Mu spike is more resistant to serum-mediated neutralization than all other currently recognized variants of interest (VOI) and concern (VOC). This includes the Beta variant (B.1.351) that has been suggested to represent the most resistant variant to convalescent and vaccinated sera to date.

Biorxiv Preprint: Ineffective neutralization of the SARS-CoV-2 Mu variant by convalescent and vaccine sera

 

The stunning rise of the Mu variant

 

 

 

Image by Sofia Cristina Córdova Valladares from Pixabay