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Immune plasma of #COVID19 convalescent blood donors had 6-fold less neutralizing capacity against the #P1 variant than against the B-lineage

America, Brazil, Coronavirus, Health, Infection, Mutation, P.1, Reinfection, Science, Vaccine

The immune plasma of COVID-19 convalescent blood donors had 6-fold less neutralizing capacity against the P.1 than against the B-lineage. Moreover, five months after booster immunization with CoronaVac, plasma from vaccinated individuals failed to efficiently neutralize P.1 lineage isolates.

Interpretation: These data indicate that the P.1 lineage may escape from neutralizing antibodies generated in response to polyclonal stimulation against previously circulating variants of SARS-CoV-2.

The Lancet Preprint

 

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