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84% reduction in humoral immunity among healthcare workers and nursing home residents after 6 months

Coronavirus, Elderly, Health, Healthcare, Infection, Pfizer/Biontech, Revaccination, USA, Vaccine, Vaccine Breakthrough, Vaccine Waning

We report on humoral immunity from 2 weeks to 6-months post-vaccination in 120 nursing home residents and 92 ambulatory healthcare worker controls with and without pre-vaccination SARS-CoV-2 infection. Anti-spike, anti-RBD and neutralization levels dropped more than 84% over 6 months’ time in all groups irrespective of prior SARS-CoV-2 infection. At 6 months post-vaccine, 70% of the infection-naive NH residents had neutralization titers at or below the lower limit of detection compared to 16% at 2 weeks after full vaccination.

Anti-spike and anti-receptor binding domain (RBD) IgG, and serum neutralization titers, were assessed using a bead-based ELISA method and pseudovirus neutralization assay.

 

Medrxiv Preprint: Significant reduction in humoral immunity among healthcare workers and nursing home residents 6 months after COVID-19 BNT162b2 mRNA vaccination 

 

Image by Gundula Vogel from Pixabay

** This post was originally published on September 7, 2021 **