Tag: RBD
Preprint: Coronaviruses with a SARS-CoV-2-like RBD isolated from bats of the Indochinese peninsula
“We found that the RBDs of these viruses differ from that of SARS-CoV-2 by only one or two residues”
Here we show that such viruses indeed circulate in cave bats living in the limestone karstic terrain in North Laos, within the Indochinese peninsula. More...
84% reduction in humoral immunity among healthcare workers and nursing home residents after 6 months
We report on humoral immunity from 2 weeks to 6-months post-vaccination in 120 nursing home residents and 92 ambulatory healthcare worker controls with and without pre-vaccination SARS-CoV-2 infection. More...
Preprint: Persistent coronavirus infection and intra-host evolution in association with advanced HIV infection
“Here we present a case of prolonged infection of greater than 6 months with shedding of high titer SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure. More...
Denmark: Sars-CoV-2 coronavirus spike mutations arising in Danish mink – the Cluster 5 report
This study investigates the amino acid changes in the spike surface glycoprotein that appeared during this outbreak [in mink] and their effect on the antigenicity of the SARS-CoV-2 virus. More...
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 coronavirus
In this work, we reconstruct the evolutionary events that have accompanied the emergence of SARS-CoV-2, with a special emphasis on the RBD and its adaptation for binding to its receptor, human ACE2 (hACE2). More...
Antibody resistance of coronavirus variants B.1.351 (SA) and B.1.1.7 (UK)
“Findings on B.1.351 [South Africa variant] are more worrisome in that this variant is not only refractory to neutralization by most NTD mAbs but also by multiple individual mAbs to the receptor-binding motif on RBD, largely owing to an E484K mutation. More...
Sars-Cov-2 lab variant bound 600 times more successfully to human cells than the original strain
The naturally selected mutations S477N, E484K, and N501Y of the Spike protein RBD, which show higher infectivity, were selected by yeast surface display affinity maturation already in the first round, giving rise to the South-African, E484K, N501Y, and British variants that bind ACE2 13 and 3.5-fold tighter than RBD-WT. More...
White-tailed deer are highly susceptible to SARS-CoV-2 infection
“Here we demonstrated that white-tailed deer, an animal species in which the angiotensin converting enzyme 2 (ACE2) – the SARS-CoV-2 receptor – shares a high degree of similarity to humans, are highly susceptible to infection. More...
Cambridge study: “Dog, cat, and cattle ACE2 receptors were identified as the strongest interactors with the SARS-CoV-2 spike protein”
Researchers investigated whether the SARS-CoV-2 spike protein could bind to the ACE2 receptors from 22 different animals to ascertain which of these, if any, may be susceptible to infection. More...