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Preprint: Persistent #coronavirus infection and intra-host evolution in association with advanced HIV infection

Africa, Co-infection, Coronavirus, D614G, E484K, Health, Infection, K417T, Mutation, N501Y, PCR, Science, South Africa, Testing, Transmission, Treatment, Variants, Y144

“Here we present a case of prolonged infection of greater than 6 months with shedding of high titer SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure. …Through whole genome sequencing at multiple time-points, we demonstrate the early emergence of the E484K substitution associated with escape from neutralizing antibodies, followed by other escape mutations and the N501Y substitution found in most variants of concern.”

Preprint: Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV
infection

 

 

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