Category: N501Y

France: new coronavirus variant B.1.640 detected in Finistère, Brittany

A new coronavirus variant has been identified in a school in Finistère in October 2021, and named B.1.640.  Twenty-four people, 18 children and six adults in contact with them, have been affected by this new mutation that is unlike any other.… ...More...

Coronaheadsup.com Africa, B.1.640, Coronavirus, D614G, Europe, Evolution, France, Infection, N501Y, P681H, Republic of Congo, Testing, Transmission, Variants

Delta 4+ variant: Complete vaccine escape & enhanced infectivity with Pfizer vaccine

“Here we suggest an evolutionary pathway by which the Delta variant could achieve complete escape from vaccine-induced immunity”.   Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity.… ...More...

Coronaheadsup.com B.1.617.2, Coronavirus, Delta, E484K, Infection, K417N, Mutation, N439K, N501Y, Pfizer/Biontech, Vaccine, Vaccine Breakthrough, Variants

Preprint: Characterization of the emerging B.1.621 variant of interest of SARS-CoV-2

In this study, we reported the emergence and spread of the novel B.1.621 lineage of SARS-CoV-2, a new VOI with the insertion 146N and several amino acid substitutions in the Spike protein (T95I,Y144T, Y145S, R346K, E484K, N501Y and P681H).… ...More...

Coronaheadsup.com America, B.1.621, Belgium, Colombia, Coronavirus, E484K, Genome, Infection, Mutation, N501Y, P681H, Science, Testing, Transmission, Vaccine Breakthrough, Y144

Preprint: Persistent #coronavirus infection and intra-host evolution in association with advanced HIV infection

“Here we present a case of prolonged infection of greater than 6 months with shedding of high titer SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure.… ...More...

Coronaheadsup.com Africa, Co-infection, Coronavirus, D614G, E484K, Health, Infection, K417T, Mutation, N501Y, PCR, Science, South Africa, Testing, Transmission, Treatment, Variants, Y144

France: 46 cases of B.1.1.7 with E484Q mutation in Bordeaux #coronavirus outbreak of VOC 20I/484Q

The French city of Bordeaux is to fast-track vaccinations for residents in one neighbourhood, opening access the jab for all adults after nearly 50 people tested positive for a “very rare” variant of Covid-19. 

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Coronaheadsup.com 20I/484Q, B.1.1.7, Coronavirus, E484Q, Europe, France, Infection, N501Y, Science, Testing, Transmission, UK, Vaccine

UK: #coronavirus variant B.1.617.2 within hours of outcompeting B.1.1.7 in Britain

Well that escalated quickly. It took just a little over one month to do it, but B.1.617.2 is now just hours away from outcompeting B.1.1.7 (aka the UK or Kent variant) on a national scale in Great Britain.… ...More...

Coronaheadsup.com Asia, B.1.1.7, B.1.617, B.1.617.1, B.1.617.2, B.1.617.3, Coronavirus, D614G, Delta, E484K, England, Health, India, Infection, L452R, London, N501Y, Northern Ireland, P681H, Science, Scotland, T478K, Testing, UK, Variants, Wales

UK SAGE: Lab studies suggest that the N501Y spike protein mutation increases binding to rat and mouse ACE2 leading to viral replication

A report issued by the UK government’s Scientific Advisory Group for Emergencies (SAGE) found the likelihood that a variant of concern (VOC) that has arisen in humans could infect a rodent and then spread among the animals is high.… ...More...

Coronaheadsup.com Animals, B.1.1.7, B.1.351, Coronavirus, England, Health, Infection, London, N501Y, Northern Ireland, P.1, Reservoir, Science, Scotland, Testing, Transmission, UK, Wales

1,039 cases of Brazilian #coronavirus variant P.1 reported in Canada

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Coronaheadsup.com Alberta, America, British Columbia, Canada, Coronavirus, E484K, Health, Infection, Mutation, N501Y, Ontario, P.1, Quebec, Science, Testing, Transmission, Variants

Detection of 54 cases of the P.1 variant in Massachusetts in less than a month

All three global VoCs (B.1.1.7, B.1.351, and P.1) have now been detected in MA. However, unlike B.1.1.7 and B.1.351, P.1 has shown a rapid rise in frequency in the few weeks following its first detection on March 16th, 2021. … ...More...

Coronaheadsup.com America, Brazil, Connecticut, Coronavirus, E484K, Health, Infection, Maine, Massachusetts, N501Y, P.1, PCR, Rhode Island, Science, Testing, Transmission