Category: B.1.1.7
Preprint: Genome recombination between Delta and Alpha variants of SARS-CoV-2
Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from clinical specimens in Japan.
During the surveillance, we monitored several variants of concern (VOCs) of the PANGO lineage. We found six unique specimens among the 21A (Delta) clade isolates that exhibited a low quality assignment (“not determined” or “none”) in the PANGO lineage, even though their genome sequences had been completely determined with high read coverage throughout the whole genome region.
A detailed genome alignment by Nextclade suggested that despite being clonal isolates of the 21A (Delta) clade, these six isolates show identical mutation profiles with 20I (Alpha, V1), particularly between the ORF6 and N genes, located towards the latter part of the SARS-CoV-2 genome.
Additionally, the alignment clearly revealed a possible recombination spot between the ORF6 and ORF7a genes. However, the next generation sequencing (NGS)-based read mapping analysis did not indicate the presence of any heterogeneous mix of alleles in the clinical specimens, suggesting that these patients had not acquired multiple variant infections with 21A (Delta) and 20I (Alpha, V1) clades at the acute stage of the infection.
MedRxiv preprint: Genome Recombination between Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Image by Iván Tamás from Pixabay
Vaccine breakthrough cases in Oregon by variant to 16th September 2021
Vaccine breakthrough data for Oregon state by Sars-CoV-2 variant up to 16th September 2021.
The Delta variant is currently responsible for the majority of vaccine breakthrough cases in Oregon. Oregon state is currently sequencing about 5% of their case samples.
Vaccine breakthroughs in Oregon to 16 September 2021. The cumulative total is now 19,549 breakthrough cases.
| 16th Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|
| Alpha | B.1.1.7 | 140 | 0 |
| Gamma | P.1 | 47 | 1 |
| Epsilon | B.1.427/429 | 38 | 0 |
| Delta | B.1.617.2 | 690 | 111 |
| Iota | B.1.526 | 29 | 0 |
| Beta | B.1.351 | 16 | 0 |
| Sequenced | Sequenced | 960 | 112 |
| Weekly Total of all VB cases | Weekly Total of all VB cases | 2632 | -242 |
Vaccine breakthroughs in Oregon to 09 September 2021. The cumulative total is now 16,417 breakthrough cases.
| 9th Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant |
|---|---|---|
| Alpha | B.1.1.7 | 140 |
| Gamma | P.1 | 46 |
| Epsilon | B.1.427/429 | 38 |
| Delta | B.1.617.2 | 579 |
| Iota | B.1.526 | 29 |
| Beta | B.1.351 | 16 |
| Sequenced | Sequenced | 848 |
| Weekly Total of all VB cases | Weekly Total of all VB cases | 2874 |
Source: Oregon Vaccine Breakthrough file
Vaccine breakthrough cases in Washington State to 15th September 2021
This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 15th September 2021. The Delta variant continues to be the leading cause of breakthrough infections in the state, however a big drop in the number of cases being sequenced means that this data doesn’t have much statistical relevance to the actual number of breakthrough infections occurring.
The data might, however, be a useful indicator of the rising importance of new variants in the future, and on that basis we will continue to publish the information
Vaccine Breakthroughs up to 15th September 2021
| 15th Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 407 | 12% | 31% | 5 |
| Gamma | P.1 | 202 | 6% | 7% | 3 |
| Epsilon | B.1.429 | 126 | 4% | 11% | 2 |
| Delta | B.1.617.2 | 2450 | 73% | 30% | 190 |
| Iota | B.1.526 | 35 | 1% | 3% | 1 |
| Beta | B.1.351 | 11 | 0% | 1% | 0 |
| Epsilon | B.1.427 | 13 | 0% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| B.1.617.3 | B.1.617.3 | 0 | 0% | 0% | 0 |
| Other | Other | 108 | 3% | 15% | 3 |
| Total | Total | 3359 | 100% | 100% | 204 |
Vaccine Breakthroughs up to 8th September 2021
| 8th Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 402 | 13% | 32% | 3 |
| Gamma | P.1 | 199 | 6% | 7% | 3 |
| Epsilon | B.1.429 | 124 | 4% | 11% | 0 |
| Delta | B.1.617.2 | 2260 | 72% | 29% | 423 |
| Iota | B.1.526 | 34 | 1% | 2% | 0 |
| Beta | B.1.351 | 11 | 0% | 1% | 0 |
| Epsilon | B.1.427 | 13 | 0% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| B.1.617.3 | B.1.617.3 | 0 | 0% | 0% | 0 |
| Other | Other | 105 | 3% | 16% | -7 |
| Total | Total | 3155 | 100% | 100% | 422 |
Vaccine Breakthroughs up to 1st September 2021
| 1st Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 399 | 15% | 33% | 1 |
| Gamma | P.1 | 196 | 7% | 8% | -2 |
| Epsilon | B.1.429 | 124 | 5% | 12% | 0 |
| Delta | B.1.617.2 | 1837 | 67% | 25% | 443 |
| Iota | B.1.526 | 34 | 1% | 2% | 0 |
| Beta | B.1.351 | 11 | 0% | 1% | 0 |
| Epsilon | B.1.427 | 13 | 0% | 1% | 1 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| B.1.617.3 | B.1.617.3 | 0 | 0% | 0% | 0 |
| Other | Other | 112 | 4% | 18% | -111 |
| Total | Total | 2733 | 100% | 100% | 332 |
Vaccine Breakthroughs up to 25th August 2021
| 25th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 1394 | 58% | 18% | 546 |
| Alpha | B.1.1.7 | 398 | 17% | 31% | 40 |
| Gamma | P.1 | 198 | 8% | 7% | 12 |
| Epsilon | B.1.429 | 124 | 5% | 11% | 7 |
| Iota | B.1.526 | 34 | 1% | 2% | 6 |
| Epsilon | B.1.427 | 12 | 0% | 1% | 1 |
| Beta | B.1.351 | 11 | 0% | 1% | 1 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| Other | Other | 223 | 9% | 27% | -540 |
| Total | Total | 2401 | 100% | 100% | 73 |
Vaccine Breakthroughs up to 18th August 2021
| 18th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 848 | 36% | 12% | 219 |
| Alpha | B.1.1.7 | 358 | 15% | 30% | 6 |
| Gamma | P.1 | 186 | 8% | 7% | 4 |
| Epsilon | B.1.429 | 117 | 5% | 11% | 1 |
| Iota | B.1.526 | 28 | 1% | 2% | 0 |
| Epsilon | B.1.427 | 11 | 0% | 1% | 0 |
| Beta | B.1.351 | 10 | 0% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 2 |
| Other | Other | 763 | 33% | 35% | 676 |
| Total | Total | 2328 | 100% | 100% | 908 |
Vaccine Breakthroughs up to 11th August 2021
| 11th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 629 | 44% | 12% | 224 |
| Alpha | B.1.1.7 | 352 | 25% | 39% | 9 |
| Gamma | P.1 | 182 | 13% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 8% | 14% | 0 |
| Iota | B.1.526 | 28 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 87 | 6% | 20% | 37 |
| Total | Total | 1420 | 100% | 100% | 278 |
Vaccine Breakthroughs up to 4th August 2021
| 4th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 405 | 35% | 10% | 151 |
| Alpha | B.1.1.7 | 343 | 30% | 41% | 6 |
| Gamma | P.1 | 175 | 15% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 10% | 15% | 0 |
| Iota | B.1.526 | 27 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 50 | 4% | 19% | -4 |
| Total | 1142 | 100% | 100% | 161 |
Vaccine Breakthroughs up to 28th July 2021
| 28th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 337 | 34% | 43% | 29 |
| Gamma | P.1 | 168 | 17% | 10% | 12 |
| Epsilon | B.1.429 | 116 | 12% | 15% | 3 |
| Delta | B.1.617.2 | 254 | 26% | 7% | 141 |
| Iota | B.1.526 | 26 | 3% | 3% | 4 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 54 | 6% | 18% | 4 |
| Total | 981 | 100% | 100% | 193 |
Vaccine Breakthroughs up to 21st July 2021
| 21st July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 308 | 39% | 44% | -1 |
| Gamma | P.1 | 156 | 20% | 10% | 9 |
| Epsilon | B.1.429 | 113 | 14% | 16% | 0 |
| Delta | B.1.617.2 | 113 | 14% | 4% | 23 |
| Iota | B.1.526 | 22 | 3% | 3% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | -1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 50 | 6% | 19% | 0 |
| Total | 788 | 100% | 100% | 30 |
Vaccine Breakthroughs up to 14th July 2021
| 14th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 309 | 41% | 44% | 12 |
| Gamma | P.1 | 147 | 19% | 10% | 6 |
| Epsilon | B.1.429 | 113 | 15% | 16% | 0 |
| Delta | B.1.617.2 | 90 | 12% | 4% | 20 |
| Iota | B.1.526 | 22 | 3% | 3% | 1 |
| Beta | B.1.351 | 11 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 49 | 6% | 20% | 0 |
| Total | 757 | 100% | 100% | 39 |
Vaccine Breakthroughs up to 7th July 2021
| 7th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 297 | 41% | 44% | 11 |
| Gamma | P.1 | 139 | 19% | 9% | 6 |
| Epsilon | B.1.429 | 113 | 16% | 16% | 0 |
| Delta | B.1.617.2 | 70 | 10% | 4% | 30 |
| Iota | B.1.526 | 21 | 3% | 3% | 7 |
| Beta | B.1.351 | 11 | 2% | 1% | 1 |
| Epsilon | B.1.427 | 11 | 2% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | 49 | 7% | 20% | 0 | |
| Total | 716 | 100% | 100% | 55 |
Vaccine Breakthroughs up to 30th June 2021
| 30th June 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant |
|---|---|---|---|---|
| Alpha | B.1.1.7 | 286 | 37% | 38% |
| Gamma | P.1 | 133 | 17% | 8% |
| Epsilon | B.1.429 | 113 | 15% | 14% |
| Delta | B.1.617.2 | 40 | 5% | 2% |
| Iota | B.1.526 | 14 | 2% | 3% |
| Beta | B.1.351 | 10 | 1% | 1% |
| Epsilon | B.1.427 | 11 | 1% | 2% |
| Eta | B.1.525 | 4 | 1% | 0% |
| Kappa | B.1.617.1 | 1 | 0% | 0% |
| Zeta | P.2 | 0 | 0% | 0% |
| Other | 49 | 21% | 32% | |
| Totals | 661 | 100% | 100% |
UK: The Alpha variant rears its ugly head again
A big surprise in the latest UK sequencing figures show that the Alpha variant has made something of a comeback this week. Even though the percentage of Alpha cases is still tiny compared to that of Delta, the figure of more than 400 Alpha cases is the highest since mid-June 2021.
It’s unclear whether this is a localised outbreak (it may be part of the unfolding superspreader event of the Boardmasters festival in Cornwall for example), or whether these are cases scattered across the UK, but to see such a resurgence after so many weeks of Delta dominance is something of a shock as the Alpha variant was far less effective at breaking through vaccine protection than the Delta variant is.
After weeks of just a handful of Alpha cases in the UK, there is suddenly a spike of over 400 new cases:
Confirmation that the Delta variant has dipped recently:
Charts and data courtesy of CovSpectrum.org
Vaccine breakthrough cases in Washington State to 1st September 2021
This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 1st September 2021. This week, the Delta variant has posted another large increase for vaccine breakthroughs, and, as it is now the predominant variant in the region, will presumably continue to do so for some time to come.
Much of the backlog of virus genome sequencing that built up two weeks ago appears to have been cleared, so there is a big reduction in sequences listed under the “other” category this week. Those sequences have now been largely identified and have moved mostly to the Delta row.
There is a newer version of this post here
Vaccine Breakthroughs up to 1st September 2021
| 1st Sept 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 399 | 15% | 33% | 1 |
| Gamma | P.1 | 196 | 7% | 8% | -2 |
| Epsilon | B.1.429 | 124 | 5% | 12% | 0 |
| Delta | B.1.617.2 | 1837 | 67% | 25% | 443 |
| Iota | B.1.526 | 34 | 1% | 2% | 0 |
| Beta | B.1.351 | 11 | 0% | 1% | 0 |
| Epsilon | B.1.427 | 13 | 0% | 1% | 1 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| B.1.617.3 | B.1.617.3 | 0 | 0% | 0% | 0 |
| Other | Other | 112 | 4% | 18% | -111 |
| Total | Total | 2733 | 100% | 100% | 332 |
Vaccine Breakthroughs up to 25th August 2021
| 25th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 1394 | 58% | 18% | 546 |
| Alpha | B.1.1.7 | 398 | 17% | 31% | 40 |
| Gamma | P.1 | 198 | 8% | 7% | 12 |
| Epsilon | B.1.429 | 124 | 5% | 11% | 7 |
| Iota | B.1.526 | 34 | 1% | 2% | 6 |
| Epsilon | B.1.427 | 12 | 0% | 1% | 1 |
| Beta | B.1.351 | 11 | 0% | 1% | 1 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| Other | Other | 223 | 9% | 27% | -540 |
| Total | Total | 2401 | 100% | 100% | 73 |
Vaccine Breakthroughs up to 18th August 2021
| 18th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 848 | 36% | 12% | 219 |
| Alpha | B.1.1.7 | 358 | 15% | 30% | 6 |
| Gamma | P.1 | 186 | 8% | 7% | 4 |
| Epsilon | B.1.429 | 117 | 5% | 11% | 1 |
| Iota | B.1.526 | 28 | 1% | 2% | 0 |
| Epsilon | B.1.427 | 11 | 0% | 1% | 0 |
| Beta | B.1.351 | 10 | 0% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 2 |
| Other | Other | 763 | 33% | 35% | 676 |
| Total | Total | 2328 | 100% | 100% | 908 |
Vaccine Breakthroughs up to 11th August 2021
| 11th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 629 | 44% | 12% | 224 |
| Alpha | B.1.1.7 | 352 | 25% | 39% | 9 |
| Gamma | P.1 | 182 | 13% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 8% | 14% | 0 |
| Iota | B.1.526 | 28 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 87 | 6% | 20% | 37 |
| Total | Total | 1420 | 100% | 100% | 278 |
Vaccine Breakthroughs up to 4th August 2021
| 4th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 405 | 35% | 10% | 151 |
| Alpha | B.1.1.7 | 343 | 30% | 41% | 6 |
| Gamma | P.1 | 175 | 15% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 10% | 15% | 0 |
| Iota | B.1.526 | 27 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 50 | 4% | 19% | -4 |
| Total | 1142 | 100% | 100% | 161 |
Vaccine Breakthroughs up to 28th July 2021
| 28th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 337 | 34% | 43% | 29 |
| Gamma | P.1 | 168 | 17% | 10% | 12 |
| Epsilon | B.1.429 | 116 | 12% | 15% | 3 |
| Delta | B.1.617.2 | 254 | 26% | 7% | 141 |
| Iota | B.1.526 | 26 | 3% | 3% | 4 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 54 | 6% | 18% | 4 |
| Total | 981 | 100% | 100% | 193 |
Vaccine Breakthroughs up to 21st July 2021
| 21st July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 308 | 39% | 44% | -1 |
| Gamma | P.1 | 156 | 20% | 10% | 9 |
| Epsilon | B.1.429 | 113 | 14% | 16% | 0 |
| Delta | B.1.617.2 | 113 | 14% | 4% | 23 |
| Iota | B.1.526 | 22 | 3% | 3% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | -1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 50 | 6% | 19% | 0 |
| Total | 788 | 100% | 100% | 30 |
Vaccine Breakthroughs up to 14th July 2021
| 14th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 309 | 41% | 44% | 12 |
| Gamma | P.1 | 147 | 19% | 10% | 6 |
| Epsilon | B.1.429 | 113 | 15% | 16% | 0 |
| Delta | B.1.617.2 | 90 | 12% | 4% | 20 |
| Iota | B.1.526 | 22 | 3% | 3% | 1 |
| Beta | B.1.351 | 11 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 49 | 6% | 20% | 0 |
| Total | 757 | 100% | 100% | 39 |
Vaccine Breakthroughs up to 7th July 2021
| 7th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 297 | 41% | 44% | 11 |
| Gamma | P.1 | 139 | 19% | 9% | 6 |
| Epsilon | B.1.429 | 113 | 16% | 16% | 0 |
| Delta | B.1.617.2 | 70 | 10% | 4% | 30 |
| Iota | B.1.526 | 21 | 3% | 3% | 7 |
| Beta | B.1.351 | 11 | 2% | 1% | 1 |
| Epsilon | B.1.427 | 11 | 2% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | 49 | 7% | 20% | 0 | |
| Total | 716 | 100% | 100% | 55 |
Vaccine Breakthroughs up to 30th June 2021
| 30th June 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant |
|---|---|---|---|---|
| Alpha | B.1.1.7 | 286 | 37% | 38% |
| Gamma | P.1 | 133 | 17% | 8% |
| Epsilon | B.1.429 | 113 | 15% | 14% |
| Delta | B.1.617.2 | 40 | 5% | 2% |
| Iota | B.1.526 | 14 | 2% | 3% |
| Beta | B.1.351 | 10 | 1% | 1% |
| Epsilon | B.1.427 | 11 | 1% | 2% |
| Eta | B.1.525 | 4 | 1% | 0% |
| Kappa | B.1.617.1 | 1 | 0% | 0% |
| Zeta | P.2 | 0 | 0% | 0% |
| Other | 49 | 21% | 32% | |
| Totals | 661 | 100% | 100% |
Photo by Alex Mertz on Unsplash
Vaccine breakthrough cases in Washington State to 25th August 2021
This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 25th August 2021. It looks like Washington State have spent the last week cataloguing Delta samples from the previous week, as very few new breakthrough cases have been recorded this week.
Although Delta breakthroughs have seemingly increased over the week, they have mostly been moved from the “other” row where they were posted last week into the Delta column this week, as we predicted they would be last week.
We will continue to reprint these figures as long as Washington State continues to publish them, but, sadly, their value is increasingly doubtful due to an obvious lag in sequencing the samples.
Vaccine Breakthroughs up to 25th August 2021
| 25th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 1394 | 58% | 18% | 546 |
| Alpha | B.1.1.7 | 398 | 17% | 31% | 40 |
| Gamma | P.1 | 198 | 8% | 7% | 12 |
| Epsilon | B.1.429 | 124 | 5% | 11% | 7 |
| Iota | B.1.526 | 34 | 1% | 2% | 6 |
| Epsilon | B.1.427 | 12 | 0% | 1% | 1 |
| Beta | B.1.351 | 11 | 0% | 1% | 1 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 0 |
| Other | Other | 223 | 9% | 27% | -540 |
| Total | Total | 2401 | 100% | 100% | 73 |
Vaccine Breakthroughs up to 18th August 2021
| 18th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 848 | 36% | 12% | 219 |
| Alpha | B.1.1.7 | 358 | 15% | 30% | 6 |
| Gamma | P.1 | 186 | 8% | 7% | 4 |
| Epsilon | B.1.429 | 117 | 5% | 11% | 1 |
| Iota | B.1.526 | 28 | 1% | 2% | 0 |
| Epsilon | B.1.427 | 11 | 0% | 1% | 0 |
| Beta | B.1.351 | 10 | 0% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 3 | 0% | 0% | 2 |
| Other | Other | 763 | 33% | 35% | 676 |
| Total | Total | 2328 | 100% | 100% | 908 |
Vaccine Breakthroughs up to 11th August 2021
| 11th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 629 | 44% | 12% | 224 |
| Alpha | B.1.1.7 | 352 | 25% | 39% | 9 |
| Gamma | P.1 | 182 | 13% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 8% | 14% | 0 |
| Iota | B.1.526 | 28 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 87 | 6% | 20% | 37 |
| Total | Total | 1420 | 100% | 100% | 278 |
Vaccine Breakthroughs up to 4th August 2021
| 4th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 405 | 35% | 10% | 151 |
| Alpha | B.1.1.7 | 343 | 30% | 41% | 6 |
| Gamma | P.1 | 175 | 15% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 10% | 15% | 0 |
| Iota | B.1.526 | 27 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 50 | 4% | 19% | -4 |
| Total | 1142 | 100% | 100% | 161 |
Vaccine Breakthroughs up to 28th July 2021
| 28th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 337 | 34% | 43% | 29 |
| Gamma | P.1 | 168 | 17% | 10% | 12 |
| Epsilon | B.1.429 | 116 | 12% | 15% | 3 |
| Delta | B.1.617.2 | 254 | 26% | 7% | 141 |
| Iota | B.1.526 | 26 | 3% | 3% | 4 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 54 | 6% | 18% | 4 |
| Total | 981 | 100% | 100% | 193 |
Vaccine Breakthroughs up to 21st July 2021
| 21st July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 308 | 39% | 44% | -1 |
| Gamma | P.1 | 156 | 20% | 10% | 9 |
| Epsilon | B.1.429 | 113 | 14% | 16% | 0 |
| Delta | B.1.617.2 | 113 | 14% | 4% | 23 |
| Iota | B.1.526 | 22 | 3% | 3% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | -1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 50 | 6% | 19% | 0 |
| Total | 788 | 100% | 100% | 30 |
Vaccine Breakthroughs up to 14th July 2021
| 14th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 309 | 41% | 44% | 12 |
| Gamma | P.1 | 147 | 19% | 10% | 6 |
| Epsilon | B.1.429 | 113 | 15% | 16% | 0 |
| Delta | B.1.617.2 | 90 | 12% | 4% | 20 |
| Iota | B.1.526 | 22 | 3% | 3% | 1 |
| Beta | B.1.351 | 11 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 49 | 6% | 20% | 0 |
| Total | 757 | 100% | 100% | 39 |
Vaccine Breakthroughs up to 7th July 2021
| 7th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 297 | 41% | 44% | 11 |
| Gamma | P.1 | 139 | 19% | 9% | 6 |
| Epsilon | B.1.429 | 113 | 16% | 16% | 0 |
| Delta | B.1.617.2 | 70 | 10% | 4% | 30 |
| Iota | B.1.526 | 21 | 3% | 3% | 7 |
| Beta | B.1.351 | 11 | 2% | 1% | 1 |
| Epsilon | B.1.427 | 11 | 2% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | 49 | 7% | 20% | 0 | |
| Total | 716 | 100% | 100% | 55 |
Vaccine Breakthroughs up to 30th June 2021
| 30th June 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant |
|---|---|---|---|---|
| Alpha | B.1.1.7 | 286 | 37% | 38% |
| Gamma | P.1 | 133 | 17% | 8% |
| Epsilon | B.1.429 | 113 | 15% | 14% |
| Delta | B.1.617.2 | 40 | 5% | 2% |
| Iota | B.1.526 | 14 | 2% | 3% |
| Beta | B.1.351 | 10 | 1% | 1% |
| Epsilon | B.1.427 | 11 | 1% | 2% |
| Eta | B.1.525 | 4 | 1% | 0% |
| Kappa | B.1.617.1 | 1 | 0% | 0% |
| Zeta | P.2 | 0 | 0% | 0% |
| Other | 49 | 21% | 32% | |
| Totals | 661 | 100% | 100% |
Image by USA-Reiseblogger from Pixabay
UK Covid app confirms vaccines are waning
Joinzoe: “We found that initial protection against infection a month after the second dose of the Pfizer vaccine was 88%, while after five to six months this fell to 74%. For the AstraZeneca vaccine, there was around 77% protection a month after the second dose, falling to 67% after four to five months.
This analysis included:
- 411,642 test results from users who were doubly vaccinated with the Pfizer mRNA vaccine at the time of the infection
- 709,486 test results from users who were doubly vaccinated with the AstraZeneca vaccine
- 76,051 test results from users who were not yet vaccinated at the time of the infection
We found that initial protection against infection a month after the second dose of the Pfizer vaccine was 88%, while after five to six months this fell to 74%.”
Professor Tim Spector, lead scientist at the ZOE COVID Study, says:
“A reasonable worst-case scenario could see protection below 50 percent for the elderly and healthcare workers by winter. With high levels of infection in the UK, driven by loosened social restrictions and a highly transmissible variant, this scenario could mean increased hospitalisations and deaths.
Joinzoe Covid App: Is COVID vaccine protection fading?
UK: Vaccine breakthrough rate for Delta infections still increasing
The future of Sars-CoV-2: Multiple vaccine breakthrough infections in one patient
The patient had three RT-PCR confirmed SARS-CoV-2 infections. Two breakthrough infections occurred in quick succession with the first over 3 weeks after complete vaccination with COVISHIELD and despite post-vaccination seroconversion. The first breakthrough infection was due to the Alpha variant and the second due to the Delta variant. The Delta variant infection resulted in hypoxia, hospitalization, and illness lasting seven weeks. Serial serology, acute phase reactants, and chest imaging supported WGS in establishing distinct episodes of infection. WGS established a fully vaccinated family member as the index case.
Research article: Severe SARS-CoV-2 Breakthrough Reinfection With Delta Variant After Recovery From Breakthrough Infection by Alpha Variant in a Fully Vaccinated Health Worker
Preprint: Just three mutations for SARS-CoV-2 to escape from highly neutralizing convalescent plasma
UK: Vaccine breakthrough rate for Delta infections still increasing
The latest UK PHE Technical Briefing has just been published, and it shows that the vaccine breakthrough rate for Delta infections in the UK continues to increase by about 6% per month. The curious conundrum of the fully vaccinated being more likely to die of a Delta infection than the unvaccinated also continues. Links to the relevant PHE Technical Briefing papers are given.
There is a newer version of this post here
Technical Briefing 21, 1st February 2021 to 15th August 2021.
19% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 15th August 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 386,735 | 127,091 | 183,133 | 73,372 | 19% | vaccine breakthrough |
| Delta deaths | 1,189 | 390 | 679 | |||
| Percentage | 0.21% | 0.93% | 335% | greater chance of dying if fully vaccinated |
Technical Briefing 20, 1st February 2021 to 2nd August 2021
16% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 2nd August 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 300,010 | 98,722 | 151,054 | 47,008 | 16% | vaccine breakthrough |
| Delta deaths | 253 | 402 | ||||
| Percentage | 0.17% | 0.86% | 411% | greater chance of dying if fully vaccinated |
Technical Briefing 19, 1st February 2021 to 19th July 2021
13% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 19th July 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 229,218 | 105,298 | 121,402 | 28,773 | 13% | vaccine breakthrough |
| Delta deaths | 165 | 224 | ||||
| Percentage | 0.14% | 0.78% | 473% | greater chance of dying if fully vaccinated |
Technical Briefing 18, 1st February 2021 to 21st June [sic] 2021
9% vaccine breakthrough rate for Delta variant
| 1st February 2021 - *21st June 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 123,620 | 63,707 | 71,932 | 10,834 | 9% | vaccine breakthrough |
| Delta deaths | 92 | 118 | ||||
| Percentage | 0.13% | 1.09% | 752% | greater chance of dying if fully vaccinated |
Technical Briefing 17, 1st February 2021 to 21st June 2021
8% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 21st June 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 92,029 | 79,336 | 53,822 | 7,235 | 8% | vaccine breakthrough |
| Delta deaths | 44 | 50 | ||||
| Percentage | 0.08% | 0.69% | 745% | greater chance of dying if fully vaccinated |
Technical Briefing 16, 1st February 2021 to 14th June
7% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 14th June 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 60,624 | 53,177 | 35,521 | 4,087 | 7% | vaccine breakthrough |
| Delta deaths | 34 | 26 | ||||
| Percentage | 0.10% | 0.64% | 565% | greater chance of dying if fully vaccinated |
Technical Briefing 15, 1st February 2021 to 7th June 2021
5% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 7th June 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 33,206 | 28,738 | 19,573 | 1,785 | 5% | vaccine breakthrough |
| Delta deaths | 23 | 12 | ||||
| Percentage | 0.12% | 0.67% | 472% | greater chance of dying if fully vaccinated |
Technical Briefing 14, 1st February 2021 to 31st May 2021
3% vaccine breakthrough rate for Delta variant
| 1st February 2021 - 31st May 2021 | Total cases | Cases in last 28 days | Unvaccinated | Vaccinated with 2 doses | ||
|---|---|---|---|---|---|---|
| Delta cases | 9,427 | 7,744 | 5,172 | 267 | 3% | vaccine breakthrough |
| Delta deaths | 11 | 2 | ||||
| Percentage | 0.21% | 0.75% | 252% | greater chance of dying if fully vaccinated |
Delta vaccine breakthrough cases in Washington State quadruple in two weeks
Preprint: generation and transmission of recombinant SARS-CoV-2 viruses
We present evidence for multiple independent origins of recombinant SARS-CoV-2 viruses sampled from late 2020 and early 2021 in the United Kingdom. Their genomes carry single nucleotide polymorphisms and deletions that are characteristic of the B.1.1.7 variant of concern, but lack the full complement of lineage-defining mutations. Instead, the remainder of their genomes share contiguous genetic variation with non-B.1.1.7 viruses circulating in the same geographic area at the same time as the recombinants.
280 cases of Delta variant with N501Y, some with E484K too
Delta + Alpha + Beta + Gamma recombinant variant found in Turkey.
I'm observing some interesting development in Turkey since some weeks. Since 28/7/2021 of about 3.200 Turkish GISAID sequences around 280 are showing Delta with additional mutations: N501Y known from Alpha and E484K from Beta/Gamma.
This could mean even higher transmissibility
— Gönndalf (@drallcome) August 15, 2021
Image by Elliot Alderson from Pixabay
USA: 55% increase in Delta vaccine breakthrough cases in Washington State
This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 11th August 2021. Of note this week is another big jump for Delta B.1.617.2 vaccine breakthrough cases, which have increased by 55% from 405 to 629 in one week. There is also a sudden and rather alarming 74% increase in vaccine breakthrough cases where the Sars-CoV-2 variant is defined as “other”.
** There is an UPDATE of this post here **
Vaccine Breakthroughs up to 11th August 2021
| 11th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 629 | 44% | 12% | 224 |
| Alpha | B.1.1.7 | 352 | 25% | 39% | 9 |
| Gamma | P.1 | 182 | 13% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 8% | 14% | 0 |
| Iota | B.1.526 | 28 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 87 | 6% | 20% | 37 |
| Total | Total | 1420 | 100% | 100% | 278 |
Vaccine Breakthroughs up to 4th August 2021
| 4th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 405 | 35% | 10% | 151 |
| Alpha | B.1.1.7 | 343 | 30% | 41% | 6 |
| Gamma | P.1 | 175 | 15% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 10% | 15% | 0 |
| Iota | B.1.526 | 27 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 50 | 4% | 19% | -4 |
| Total | 1142 | 100% | 100% | 161 |
Vaccine Breakthroughs up to 28th July 2021
| 28th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 337 | 34% | 43% | 29 |
| Gamma | P.1 | 168 | 17% | 10% | 12 |
| Epsilon | B.1.429 | 116 | 12% | 15% | 3 |
| Delta | B.1.617.2 | 254 | 26% | 7% | 141 |
| Iota | B.1.526 | 26 | 3% | 3% | 4 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 54 | 6% | 18% | 4 |
| Total | 981 | 100% | 100% | 193 |
Vaccine Breakthroughs up to 21st July 2021
| 21st July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 308 | 39% | 44% | -1 |
| Gamma | P.1 | 156 | 20% | 10% | 9 |
| Epsilon | B.1.429 | 113 | 14% | 16% | 0 |
| Delta | B.1.617.2 | 113 | 14% | 4% | 23 |
| Iota | B.1.526 | 22 | 3% | 3% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | -1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 50 | 6% | 19% | 0 |
| Total | 788 | 100% | 100% | 30 |
Vaccine Breakthroughs up to 14th July 2021
| 14th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 309 | 41% | 44% | 12 |
| Gamma | P.1 | 147 | 19% | 10% | 6 |
| Epsilon | B.1.429 | 113 | 15% | 16% | 0 |
| Delta | B.1.617.2 | 90 | 12% | 4% | 20 |
| Iota | B.1.526 | 22 | 3% | 3% | 1 |
| Beta | B.1.351 | 11 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 49 | 6% | 20% | 0 |
| Total | 757 | 100% | 100% | 39 |
Vaccine Breakthroughs up to 7th July 2021
| 7th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 297 | 41% | 44% | 11 |
| Gamma | P.1 | 139 | 19% | 9% | 6 |
| Epsilon | B.1.429 | 113 | 16% | 16% | 0 |
| Delta | B.1.617.2 | 70 | 10% | 4% | 30 |
| Iota | B.1.526 | 21 | 3% | 3% | 7 |
| Beta | B.1.351 | 11 | 2% | 1% | 1 |
| Epsilon | B.1.427 | 11 | 2% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | 49 | 7% | 20% | 0 | |
| Total | 716 | 100% | 100% | 55 |
Vaccine Breakthroughs up to 30th June 2021
| 30th June 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant |
|---|---|---|---|---|
| Alpha | B.1.1.7 | 286 | 37% | 38% |
| Gamma | P.1 | 133 | 17% | 8% |
| Epsilon | B.1.429 | 113 | 15% | 14% |
| Delta | B.1.617.2 | 40 | 5% | 2% |
| Iota | B.1.526 | 14 | 2% | 3% |
| Beta | B.1.351 | 10 | 1% | 1% |
| Epsilon | B.1.427 | 11 | 1% | 2% |
| Eta | B.1.525 | 4 | 1% | 0% |
| Kappa | B.1.617.1 | 1 | 0% | 0% |
| Zeta | P.2 | 0 | 0% | 0% |
| Other | 49 | 21% | 32% | |
| Totals | 661 | 100% | 100% |
Image by Frank Ravizza from Pixabay
USA, Maryland: “I went to a party with 14 other vaccinated people; 11 of us got COVID”
I’m an epidemiologist at a major medical research university. I had gone to a house party in Montgomery County. There were 15 adults there, all of us fully vaccinated. The next day, our host started to feel sick. The day after that, she tested positive for COVID-19. At this point, 11 of the 15 have tested positive for COVID.
Image by Bruce Emmerling from Pixabay
USA: Washington State Vaccine Breakthroughs by Variant up to 4th August 2021
This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 4th August 2021. Of note this week is another big jump for Delta B.1.617.2 vaccine breakthrough cases, which have increased from 254 to 405 in one week. Delta is now responsible for more breakthrough cases in Washington State than any other variant. There are also further small increases in vaccine breakthrough cases for the Alpha and Gamma variants.
Vaccine Breakthroughs up to 4th August 2021
| 4th August 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Delta | B.1.617.2 | 405 | 35% | 10% | 151 |
| Alpha | B.1.1.7 | 343 | 30% | 41% | 6 |
| Gamma | P.1 | 175 | 15% | 9% | 7 |
| Epsilon | B.1.429 | 116 | 10% | 15% | 0 |
| Iota | B.1.526 | 27 | 2% | 3% | 1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Other | Other | 50 | 4% | 19% | -4 |
| Total | 1142 | 100% | 100% | 161 |
Vaccine Breakthroughs up to 28th July 2021
| 28th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 337 | 34% | 43% | 29 |
| Gamma | P.1 | 168 | 17% | 10% | 12 |
| Epsilon | B.1.429 | 116 | 12% | 15% | 3 |
| Delta | B.1.617.2 | 254 | 26% | 7% | 141 |
| Iota | B.1.526 | 26 | 3% | 3% | 4 |
| Beta | B.1.351 | 10 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 0% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 54 | 6% | 18% | 4 |
| Total | 981 | 100% | 100% | 193 |
Vaccine Breakthroughs up to 21st July 2021
| 21st July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 308 | 39% | 44% | -1 |
| Gamma | P.1 | 156 | 20% | 10% | 9 |
| Epsilon | B.1.429 | 113 | 14% | 16% | 0 |
| Delta | B.1.617.2 | 113 | 14% | 4% | 23 |
| Iota | B.1.526 | 22 | 3% | 3% | 0 |
| Beta | B.1.351 | 10 | 1% | 1% | -1 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 50 | 6% | 19% | 0 |
| Total | 788 | 100% | 100% | 30 |
Vaccine Breakthroughs up to 14th July 2021
| 14th July 2021 Variant | Lineage | Number of Vaccine Breakthrough Cases With Variant | Percentage of Vaccine Breakthrough Cases With Variant | Percentage of Sequences From All Covid-19 Cases With Variant | Increase in Number of Breakthroughs From Previous Week |
|---|---|---|---|---|---|
| Alpha | B.1.1.7 | 309 | 41% | 44% | 12 |
| Gamma | P.1 | 147 | 19% | 10% | 6 |
| Epsilon | B.1.429 | 113 | 15% | 16% | 0 |
| Delta | B.1.617.2 | 90 | 12% | 4% | 20 |
| Iota | B.1.526 | 22 | 3% | 3% | 1 |
| Beta | B.1.351 | 11 | 1% | 1% | 0 |
| Epsilon | B.1.427 | 11 | 1% | 2% | 0 |
| Eta | B.1.525 | 4 | 1% | 0% | 0 |
| Kappa | B.1.617.1 | 1 | 0% | 0% | 0 |
| Zeta | P.2 | 0 | 0% | 0% | 0 |
| Other | Other | 49 | 6% | 20% | 0 |
| Total | 757 | 100% | 100% | 39 |
Image by Deborah Jackson from Pixabay