USA: 40% vaccine breakthrough in Massachusetts last week

Breakthrough infections accounted for about 40% of all cases reported in Massachusetts last week. The Massachusetts Department of Public Health has tracked a cumulative 19,443 confirmed COVID-19 infections among those fully vaccinated in the state to date and a total of 144 deaths.

NBCBoston.com report

 

 

 

Image by Oliver Fuß from Pixabay

UK: Vaccine breakthrough rate for Delta infections is 23% in Technical Briefing 22

The latest UK PHE Technical Briefing 22 has just been published, and it shows that the vaccine breakthrough rate for Delta infections in the UK continues to increase. The vaccine breakthrough rate for Delta infections is now 23%, having increased by 4% in just the last two weeks.

 

There is a later version of this post here – Technical Briefing 23

 

Technical Briefing 22, 1st February 2021 to 29th August 2021. 

23% vaccine breakthrough rate for Delta variant

Technical Briefing 22      
1st February 2021 - 29th August 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses
Delta cases492,528144,067219,716113,82323%vaccine breakthrough
Delta deaths1,7985361091
Percentage0.24%0.96%293%greater chance of dying if fully vaccinated

 

Technical Briefing 21, 1st February 2021 to 15th August 2021. 

19% vaccine breakthrough rate for Delta variant

1st February 2021 - 15th August 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases386,735127,091183,13373,37219%vaccine breakthrough
Delta deaths1,189390679
Percentage0.21%0.93%335%greater chance of dying if fully vaccinated

 

Technical Briefing 20, 1st February 2021 to 2nd August 2021

16% vaccine breakthrough rate for Delta variant

1st February 2021 - 2nd August 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases300,01098,722151,05447,00816%vaccine breakthrough
Delta deaths253402
Percentage0.17%0.86%411%greater chance of dying if fully vaccinated

 

Technical Briefing 19, 1st February 2021 to 19th July 2021

13% vaccine breakthrough rate for Delta variant

1st February 2021 - 19th July 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases229,218105,298121,40228,77313%vaccine breakthrough
Delta deaths165224
Percentage0.14%0.78%473%greater chance of dying if fully vaccinated

 

Technical Briefing 18, 1st February 2021 to 21st June [sic] 2021

9% vaccine breakthrough rate for Delta variant

1st February 2021 - *21st June 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases123,62063,70771,93210,8349%vaccine breakthrough
Delta deaths92118
Percentage0.13%1.09%752%greater chance of dying if fully vaccinated

 

Technical Briefing 17, 1st February 2021 to 21st June 2021

8% vaccine breakthrough rate for Delta variant

1st February 2021 - 21st June 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases92,02979,33653,8227,2358%vaccine breakthrough
Delta deaths4450
Percentage0.08%0.69%745%greater chance of dying if fully vaccinated

 

Technical Briefing 16, 1st February 2021 to 14th June

7% vaccine breakthrough rate for Delta variant

1st February 2021 - 14th June 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases60,62453,17735,5214,0877%vaccine breakthrough
Delta deaths3426
Percentage0.10%0.64%565%greater chance of dying if fully vaccinated

 

Technical Briefing 15, 1st February 2021 to 7th June 2021

5% vaccine breakthrough rate for Delta variant

1st February 2021 - 7th June 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases33,20628,73819,5731,7855%vaccine breakthrough
Delta deaths2312
Percentage0.12%0.67%472%greater chance of dying if fully vaccinated

 

Technical Briefing 14, 1st February 2021 to 31st May 2021

3% vaccine breakthrough rate for Delta variant

1st February 2021 - 31st May 2021Total casesCases in last 28 daysUnvaccinatedVaccinated with 2 doses  
Delta cases9,4277,7445,1722673%vaccine breakthrough
Delta deaths112
Percentage0.21%0.75%252%greater chance of dying if fully vaccinated

 

Delta vaccine breakthrough cases in Washington State quadruple in two weeks

UK: The Alpha variant rears its ugly head again

A big surprise in the latest UK sequencing figures show that the Alpha variant has made something of a comeback this week. Even though the percentage of Alpha cases is still tiny compared to that of Delta, the figure of more than 400 Alpha cases is the highest since mid-June 2021.

It’s unclear whether this is a localised outbreak (it may be part of the unfolding superspreader event of the Boardmasters festival in Cornwall for example), or whether these are cases scattered across the UK, but to see such a resurgence after so many weeks of Delta dominance is something of a shock as the Alpha variant was far less effective at breaking through vaccine protection than the Delta variant is.

After weeks of just a handful of Alpha cases in the UK, there is suddenly a spike of over 400 new cases:

 

Confirmation that the Delta variant has dipped recently:

Charts and data courtesy of CovSpectrum.org

 

 

 

Image by Josch13 from Pixabay

AY.4 Delta sub-lineage now predominant in UK and Australia, rising in the US

A post on the AY.4 sub-lineage of the Delta Sars-Cov-2 variant. Also known as B.1.617.2.4, this sub-lineage hasn’t received a lot of press attention yet, but it seems to have become the biggest sub-lineage of Delta across the globe so far. 

In the USA, the Delta AY.4 sub-lineage is currently appearing in about 20% of sequences (light blue area) according to Outbreak.info:

AY.4 Delta Sub-lineage at 19 percent of sequences in the USA

 

In the UK, AY.4 currently appears in about 46% of samples (light blue area), and is now outcompeting B.1.617.2 (dark blue area).

AY.6 seems to be coming up on the rails though at 3%:

AY.4 Delta Sub-lineage at 46 percent of all UK sequences

 

In Australia, AY.4 (dark blue area) clearly predominates over B.1.617.2 (light blue area) with 67% of sequences, B.1.617.2 is at 16% and AY.12 is at 10% :

AY.4 Delta Sub-lineage at 67 percent of sequences in Australia

 

In the USA, the estimated number of AY.4 cases was over 80,000 in early August 2021:

 

In the UK, the estimated number of AY.4 cases was about 13,000 in late August 2021

 

In Australia, the estimated number of cases was over 600 in late August 2021

 

In the USA, the demographics for AY.4 show it spreading across almost all age ranges,

 

But in the UK, AY.4 seems to be spreading amongst young children:

 

And in Australia, AY.4 seems to be spread across all age ranges:

 

The global reach of the AY.4 sub-lineage is really quite astounding considering it’s relatively recent appearance:

 

 

Further reading: New AY lineages and an update to AY.4-AY.12

 

Many thanks, as always, to the teams at Outbreak.info and covSpectrum.org for their hard work in compiling this data.

 

 

 

Image by Free-Photos from Pixabay