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Delta vaccine breakthrough cases in Washington State quadruple in two weeks

This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 18th August 2021. The Delta variant is responsible for a big increase in vaccine breakthrough cases reported by Washington State this week. Verified Delta breakthrough cases are up by 219 on last week, but there is real cause for concern for cases with variants that have not been identified by the state – they have increased by 676 in a week!

We are guessing that the 676 breakthrough cases with an unidentified variant are mostly Delta cases. We think that Washington State are now seeing so many vaccine breakthrough cases that they are simply unable to sequence them all in one week. At least we hope that’s the explanation, because the alternative is that there are unknown Sars-CoV-2 variants in Washington State that are causing far more breakthrough cases than even the Delta variant.

If the unidentified breakthrough cases are mostly Delta, that means the Delta vaccine breakthrough rate has almost quadrupled in 2 weeks.

On the 4th August, there were 405 verified Delta breakthrough cases.

On the 11th August, there were 629 verified Delta breakthrough cases plus perhaps 30 unverified, a total of 659, an increase from the previous week of ~64%.

On the 18th August, there were 848 verified Delta breakthrough cases plus perhaps 710 unverified, a total of 1558, an increase from the previous week of ~150%

There is an updated version of this file here

Vaccine Breakthroughs up to 18th August 2021

18th August 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Delta	B.1.617.2	848	36%	12%	219
Alpha	B.1.1.7	358	15%	30%	6
Gamma	P.1	186	8%	7%	4
Epsilon	B.1.429	117	5%	11%	1
Iota	B.1.526	28	1%	2%	0
Epsilon	B.1.427	11	0%	1%	0
Beta	B.1.351	10	0%	1%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	3	0%	0%	2
Other	Other	763	33%	35%	676
Total	Total	2328	100%	100%	908

Vaccine Breakthroughs up to 11th August 2021

11th August 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Delta	B.1.617.2	629	44%	12%	224
Alpha	B.1.1.7	352	25%	39%	9
Gamma	P.1	182	13%	9%	7
Epsilon	B.1.429	116	8%	14%	0
Iota	B.1.526	28	2%	3%	1
Epsilon	B.1.427	11	1%	2%	0
Beta	B.1.351	10	1%	1%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Other	Other	87	6%	20%	37
Total	Total	1420	100%	100%	278

Vaccine Breakthroughs up to 4th August 2021

4th August 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Delta	B.1.617.2	405	35%	10%	151
Alpha	B.1.1.7	343	30%	41%	6
Gamma	P.1	175	15%	9%	7
Epsilon	B.1.429	116	10%	15%	0
Iota	B.1.526	27	2%	3%	1
Epsilon	B.1.427	11	1%	2%	0
Beta	B.1.351	10	1%	1%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Other	Other	50	4%	19%	-4
Total		1142	100%	100%	161

Vaccine Breakthroughs up to 28th July 2021

28th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	337	34%	43%	29
Gamma	P.1	168	17%	10%	12
Epsilon	B.1.429	116	12%	15%	3
Delta	B.1.617.2	254	26%	7%	141
Iota	B.1.526	26	3%	3%	4
Beta	B.1.351	10	1%	1%	0
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	54	6%	18%	4
Total		981	100%	100%	193

Vaccine Breakthroughs up to 21st July 2021

21st July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	308	39%	44%	-1
Gamma	P.1	156	20%	10%	9
Epsilon	B.1.429	113	14%	16%	0
Delta	B.1.617.2	113	14%	4%	23
Iota	B.1.526	22	3%	3%	0
Beta	B.1.351	10	1%	1%	-1
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	50	6%	19%	0
Total		788	100%	100%	30

Vaccine Breakthroughs up to 14th July 2021

14th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	309	41%	44%	12
Gamma	P.1	147	19%	10%	6
Epsilon	B.1.429	113	15%	16%	0
Delta	B.1.617.2	90	12%	4%	20
Iota	B.1.526	22	3%	3%	1
Beta	B.1.351	11	1%	1%	0
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	49	6%	20%	0
Total		757	100%	100%	39

Vaccine Breakthroughs up to 7th July 2021

7th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	297	41%	44%	11
Gamma	P.1	139	19%	9%	6
Epsilon	B.1.429	113	16%	16%	0
Delta	B.1.617.2	70	10%	4%	30
Iota	B.1.526	21	3%	3%	7
Beta	B.1.351	11	2%	1%	1
Epsilon	B.1.427	11	2%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other		49	7%	20%	0
Total		716	100%	100%	55

Vaccine Breakthroughs up to 30th June 2021

30th June 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant
Alpha	B.1.1.7	286	37%	38%
Gamma	P.1	133	17%	8%
Epsilon	B.1.429	113	15%	14%
Delta	B.1.617.2	40	5%	2%
Iota	B.1.526	14	2%	3%
Beta	B.1.351	10	1%	1%
Epsilon	B.1.427	11	1%	2%
Eta	B.1.525	4	1%	0%
Kappa	B.1.617.1	1	0%	0%
Zeta	P.2	0	0%	0%
Other		49	21%	32%
Totals		661	100%	100%

Feel free to tweet us @coronaheadsup if you have an alternative take on these extraordinary numbers

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USA: 55% increase in Delta vaccine breakthrough cases in Washington State

This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them up to 11th August 2021. Of note this week is another big jump for Delta B.1.617.2 vaccine breakthrough cases, which have increased by 55% from 405 to 629 in one week. There is also a sudden and rather alarming 74% increase in vaccine breakthrough cases where the Sars-CoV-2 variant is defined as “other”.

** There is an UPDATE of this post here **

Vaccine Breakthroughs up to 11th August 2021

11th August 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Delta	B.1.617.2	629	44%	12%	224
Alpha	B.1.1.7	352	25%	39%	9
Gamma	P.1	182	13%	9%	7
Epsilon	B.1.429	116	8%	14%	0
Iota	B.1.526	28	2%	3%	1
Epsilon	B.1.427	11	1%	2%	0
Beta	B.1.351	10	1%	1%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Other	Other	87	6%	20%	37
Total	Total	1420	100%	100%	278

Vaccine Breakthroughs up to 4th August 2021

4th August 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Delta	B.1.617.2	405	35%	10%	151
Alpha	B.1.1.7	343	30%	41%	6
Gamma	P.1	175	15%	9%	7
Epsilon	B.1.429	116	10%	15%	0
Iota	B.1.526	27	2%	3%	1
Epsilon	B.1.427	11	1%	2%	0
Beta	B.1.351	10	1%	1%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Other	Other	50	4%	19%	-4
Total		1142	100%	100%	161

Vaccine Breakthroughs up to 28th July 2021

28th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	337	34%	43%	29
Gamma	P.1	168	17%	10%	12
Epsilon	B.1.429	116	12%	15%	3
Delta	B.1.617.2	254	26%	7%	141
Iota	B.1.526	26	3%	3%	4
Beta	B.1.351	10	1%	1%	0
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	0%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	54	6%	18%	4
Total		981	100%	100%	193

Vaccine Breakthroughs up to 21st July 2021

21st July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	308	39%	44%	-1
Gamma	P.1	156	20%	10%	9
Epsilon	B.1.429	113	14%	16%	0
Delta	B.1.617.2	113	14%	4%	23
Iota	B.1.526	22	3%	3%	0
Beta	B.1.351	10	1%	1%	-1
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	50	6%	19%	0
Total		788	100%	100%	30

Vaccine Breakthroughs up to 14th July 2021

14th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	309	41%	44%	12
Gamma	P.1	147	19%	10%	6
Epsilon	B.1.429	113	15%	16%	0
Delta	B.1.617.2	90	12%	4%	20
Iota	B.1.526	22	3%	3%	1
Beta	B.1.351	11	1%	1%	0
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	49	6%	20%	0
Total		757	100%	100%	39

Vaccine Breakthroughs up to 7th July 2021

7th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	297	41%	44%	11
Gamma	P.1	139	19%	9%	6
Epsilon	B.1.429	113	16%	16%	0
Delta	B.1.617.2	70	10%	4%	30
Iota	B.1.526	21	3%	3%	7
Beta	B.1.351	11	2%	1%	1
Epsilon	B.1.427	11	2%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other		49	7%	20%	0
Total		716	100%	100%	55

Vaccine Breakthroughs up to 30th June 2021

30th June 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant
Alpha	B.1.1.7	286	37%	38%
Gamma	P.1	133	17%	8%
Epsilon	B.1.429	113	15%	14%
Delta	B.1.617.2	40	5%	2%
Iota	B.1.526	14	2%	3%
Beta	B.1.351	10	1%	1%
Epsilon	B.1.427	11	1%	2%
Eta	B.1.525	4	1%	0%
Kappa	B.1.617.1	1	0%	0%
Zeta	P.2	0	0%	0%
Other		49	21%	32%
Totals		661	100%	100%

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USA: Washington State Vaccine Breakthroughs by Variant up to 21st July 2021

This week’s update from Washington State showing vaccine breakthrough cases and which Sars-CoV-2 variant is causing them. Of note this week is another large jump for Delta B.1.617.2 breakthrough cases, and a further increase for Gamma P1 breakthroughs.

Vaccine Breakthroughs up to 21st July 2021

21st July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	308	39%	44%	-1
Gamma	P.1	156	20%	10%	9
Epsilon	B.1.429	113	14%	16%	0
Delta	B.1.617.2	113	14%	4%	23
Iota	B.1.526	22	3%	3%	0
Beta	B.1.351	10	1%	1%	-1
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	50	6%	19%	0
Total		788	100%	100%	30

Vaccine Breakthroughs up to 14th July 2021

14th July 2021 Variant	Lineage	Number of Vaccine Breakthrough Cases With Variant	Percentage of Vaccine Breakthrough Cases With Variant	Percentage of Sequences From All Covid-19 Cases With Variant	Increase in Number of Breakthroughs From Previous Week
Alpha	B.1.1.7	309	41%	44%	12
Gamma	P.1	147	19%	10%	6
Epsilon	B.1.429	113	15%	16%	0
Delta	B.1.617.2	90	12%	4%	20
Iota	B.1.526	22	3%	3%	1
Beta	B.1.351	11	1%	1%	0
Epsilon	B.1.427	11	1%	2%	0
Eta	B.1.525	4	1%	0%	0
Kappa	B.1.617.1	1	0%	0%	0
Zeta	P.2	0	0%	0%	0
Other	Other	49	6%	20%	0
Total		757	100%	100%	39

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Belgium: 90-year-old woman coinfection with Alpha and Beta coronavirus variants

Researchers in Belgium report on the case of a 90-year-old woman who was simultaneously infected with two different variants of concern (VOCs) of COVID-19, in a Case Report being presented at the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) held online this year.

On March 3 2021, the woman, whose medical history was unremarkable, was admitted to the OLV Hospital in the Belgian city of Aalst after a spate of falls. She tested positive for COVID-19 on the same day. She lived alone and received nursing care at home, and had not been vaccinated against COVID-19.

Initially, there were no signs of respiratory distress and the patient had good oxygen saturation. However, she developed rapidly worsening respiratory symptoms, and died five days later.

When the patient’s respiratory sample was tested for VOCs with PCR, they discovered that she had been infected by two different strains of the virus–one which originated in the UK, known as B.1.1.7 (Alpha), and another that was first detected in South Africa (B.1.351; Beta).

The presence of both strains was confirmed by PCR on a second respiratory sample, by sequencing of the S-gene and by whole genome sequencing.

Eurekalert.org report

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UK: PHE Technical Briefing and Variants of Concern update 18

PHE England have recently published new reports on the SARS-COV-2 variants circulating in Britain: Alpha, Beta, Gamma, Zeta, Eta, B.1.1.318, Theta, Kappa, B.1.617.3, AV.1, C.36.3, Lambda, C.37

SARS-CoV-2 variants of concern and variants under investigation in England

Variants under surveillance
Variant prevalence
Secondary attack rates
SARS-CoV-2 Immunity and Reinfection Evaluation (the SIREN study) cohort monitoring

Part 2: Delta (B.1.617.2) surveillance
Surveillance through genomic data
Delta with K417N (Delta-AY.1)

Investigation of SARS-CoV-2 variants of concern: routine variant data update

Data on individual variants
Alpha
Beta
Gamma
International Epidemiology
Zeta
Eta
VUI-21FEB-04 (B.1.1.318)
Theta
Kappa
VUI-21APR-03 (B.1.617.3)
VUI-21MAY-01 (AV.1)
VUI-21MAY-02 (C.36.3)
Lambda (C.37, VUI-21JUN-01)

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Preprint: The emergence of Sars-CoV-2 coronavirus variant Lambda C.37 in South America

We report the emergence of a novel lineage of SARS-CoV-2 in South America, termed C.37. It presents seven nonsynonymous mutations in the Spike gene (Δ247-253, G75V, T76I, L452Q, F490S, T859N) and a deletion in the ORF1a gene (Δ3675-3677) also found in variants of concern (VOCs) Alpha, Beta, and Gamma. Initially reported in Lima, Peru, in late December 2020, it now accounts for 97% of Peruvian public genomes in April 2021. It is expanding in Chile and Argentina, and there is evidence of onward transmission in Colombia, Ecuador, Mexico, the USA, Germany, and Israel. On June 15, 2021, the World Health Organization designated C.37 as Variant of Interest (VOI) Lambda.

Full Medrxiv preprint: The Emergence of SARS-CoV-2 Variant Lambda (C.37) in South America

Preprint: Infectivity and immune escape of the new #coronavirus variant of interest C.37 Lambda

Peru: C.37 #coronavirus variant named Lambda by WHO

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Uganda goes into total lockdown as #coronavirus infections rise

Ugandan President Yoweri Museveni on Friday tightened restrictions in the country following a worrying rise in Covid-19 infections and deaths.

On a day when the country recorded 42 Covid-related deaths and 1,000 new infections, the Ugandan leader stopped the movement of public and private transport vehicles. Only security, emergency and other essential service providers, including the police, firefighters and the military have been exempted.

The new move tightened restrictions imposed a week ago, when cross-district travel was banned, schools closed and other public gatherings restricted yet the deaths continued to rise.

At the Mulago National Referral Hospital in the capital Kampala, a ‘technical fault’ on Wednesday cut off oxygen supply to Covid-19 patients at the facility, leading to the death of several patients. The new highest death toll would arrive two days later when the country reported 42 deaths, raising the number of those killed by the virus to more than 400.

The East African report