Delta 4+ variant: Complete vaccine escape & enhanced infectivity with Pfizer vaccine

“Here we suggest an evolutionary pathway by which the Delta variant could achieve complete escape from vaccine-induced immunity”.   Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity....More...

India: Delta Plus Delta-AY.1 dominant in Tripura – found in 138 out of 151 coronavirus sequences

At least 138 of the 151 Covid-19 samples sent by Tripura for genome sequencing have tested positive for the Delta Plus variant, State Health Surveillance Officer Dr Deep Kumar Debbarma said....More...

Poland: 106 cases of Delta and 12 cases of Delta Plus aka Delta-AY.1 coronavirus variant

Poland has confirmed 106 cases of the Delta and 12 cases of the Delta Plus (Delta-AY.1 or Delta with K417N mutation) coronavirus variants that originated in India, a deputy health minister has announced....More...

USA/UK: 2 separate clades of Delta #coronavirus variant with K417N – AY.1 and AY.2

Through routine scanning of variation in Delta, a small number of sequences were detected which had acquired the spike protein mutation K417N....More...

Nepal: nearly 20% of Delta #coronavirus sequences have K417N mutation – mountaineers variant increasing

The Nepalese Ministry of Health and Population (MoHP) said that out of 47 confirmed delta variant samples, nine were found to have K417N mutations.

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UK: Delta with K417N – the “mountaineers” variant – PHE #coronavirus Delta-AY.1 update

Of the 36 cases of Delta-AY.1 (mountaineers) variant, 27 cases were known to have a vaccination status within the National Immunisation Management System (NIMS). ...More...

India: 16% vaccine breakthrough in Delhi hospital #coronavirus study

A small-scale study on 113 healthcare workers who had received at least one vaccine dose at a private hospital in Delhi found that 18 tested positive for Covid but all except one had mild symptoms. ...More...

Efficacy of the AstraZeneca #coronavirus vaccine against the B.1.351 South African Variant

Study conclusions:  A two-dose regimen of the ChAdOx1 nCoV-19 [AstraZeneca] vaccine did not show protection against mild-to-moderate Covid-19 due to the B.1.351 [South Africa ] variant....More...

Antibody resistance of #coronavirus variants B.1.351 (SA) and B.1.1.7 (UK)

“Findings on B.1.351 [South Africa variant] are more worrisome in that this variant is not only refractory to neutralization by most NTD mAbs but also by multiple individual mAbs to the receptor-binding motif on RBD, largely owing to an E484K mutation.… ...More...