UK: Delta with K417N – the “mountaineers” variant – PHE #coronavirus Delta-AY.1 update

Of the 36 cases of Delta-AY.1 (mountaineers) variant, 27 cases were known to have a vaccination status within the National Immunisation Management System (NIMS). 

“Through routine scanning of variation in Delta a small number of sequences were detected which had acquired the spike protein mutation K417N. Information suggests that there are at least 2 separate clades of Delta with K417N. One clade is large and internationally distributed with PANGO lineage designation AY.1. A second clade found in sequences uploaded to GISAID from the USA. There is limited epidemiological information available at present.

International Epidemiology
As of 7 June 2021, 63 genomes of Delta with K417N have been identified on GISAID. from Canada (1) Germany (1), Russia (1), Nepal (2), Switzerland (4), India (6), Poland (9), Portugal (12), Japan (13), USA (14).

Epidemiology
There are currently 36 cases of Delta-AY.1 in England (35 confirmed sequencing and 1 probable genotyping) plus an additional 10 sequences which include some cases in other UK nations and some genomes for which case data is being sought. The first 5 cases were sequenced on 26 April 2021 and were contacts of travellers to Nepal and Turkey. All these cases were detected in the West Midlands. Cases have been detected in 6 different regions in England (Table 21, Figure 26). The majority of cases are in younger individuals, with 2 cases of age 60 or over (Figure 27). Out of the 36 cases, there were 11 travel associated cases (6 travellers and 5 cases amongst contacts of travellers). Twelve cases have no history of travel or contact with travellers. Countries of travel included red-list countries (Nepal and Turkey), amber-list countries (Malaysia) and green-list countries (Singapore).

Of the 36 cases, 27 cases were known to have a vaccination status within the National Immunisation Management System (NIMS), when linked on NHS number. Of these, 18 cases occurred in people who were not vaccinated, 2 cases in people who had received their first dose within 21 days of specimen date, 5 cases in people who had received their  first dose more than 21 days after specimen date. There was a total of 2 cases where there were more than 14 days between the second dose of vaccine and a positive specimen. No deaths have been recorded amongst the 36 cases.”

PHE download – SARS-CoV-2 variants of concern and variants under investigation in England  – Technical briefing 15 (PDF)

 

UK: The “mountaineers variant” – B.1.617.2 with K417N mutation

 

UK: “Everest climbers could have spread potentially more infectious and vaccine resistant’ variant

 

 

Image by Simon from Pixabay

UK: The “mountaineers variant” – B.1.617.2 with K417N mutation

The Delta variant with the K417N mutation, also known as the “Mountaineers” variant, has cropped up 14 times in Japan, and 13 of those samples were in travellers from Nepal – mostly climbers from Everest expeditions. At least 100 cases were reported at the Everest base camp, it is believed that the variant could have been spread by climbers ascending the mountain despite widespread national lockdowns across the globe.  Cases have also been identified in India, Japan, Portugal, and the UK.

According to Dr Jeff Barrett, director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute in the UK, at least one case has been found in the US.

DNAIndia.com report: Delta+K417N variant that affected at least 100 Everest climbers

 

The mountaineers variant B.1.617.2 + K417N has also been blamed for the axing of Portugal from the UK’s green travel list. See this report

 

UK: Delta with K417N – the “mountaineers” variant – PHE #coronavirus Delta-AY.1 update

 

UK: “Everest climbers could have spread potentially more infectious and vaccine resistant’ variant

 

Photo by Claire Nolan on Unsplash

Portugal: dropped from UK travel green list after just two weeks

Portugal is axed from UK’s green list and relegated to the Amber list.  No countries are set to be added to the Government’s green list. Seven countries will be added to the red rating, they are: Egypt, Sri Lanka, Costa Rica, Bahrain, Sudan, Trinidad and Tobago and Afghanistan

Telegraph report

 

The “Nepal Variant” – does it exist or is it just racist fearmongering?

 

Image by Pedro Grão from Pixabay

Portugal: could be taken off the UK’s #coronavirus travel green list for having the same infection trajectory as the UK

“UK government Ministers and their medical advisers will meet on Thursday to decide whether Portugal should be dropped from the green list and instead rated amber, requiring holidaymakers to quarantine for 10 days on their return and pay for two PCR tests.  Scientists from the Joint Biosecurity Centre (JBC) are concerned about rising infection rates and the emergence of variants in Portugal, which was the first of 12 countries and territories to be rated green just three weeks ago.”

The Telegraph.co.uk report

 

UK: PHE data shows B.1.617.2 now outcompetes B.1.1.7

 

Chart courtesy of Ourworldindata.org

EU: ECHR throws fuel on the #coronavirus vaccination fire – backs mandatory jabs for kids

The European Court of Human Rights ruled on Thursday that democratic governments can make vaccinations obligatory, in a landmark judgement rejecting complaints brought by Czech families penalised for refusing compulsory jabs for their children.

“The… measures could be regarded as being ‘necessary in a democratic society'” the court ruled, saying that the Czech health policy was consistent with the “best interests” of children.

Our opinion: ** Is there an easier or quicker way of antagonising parents in the middle of a global viral pandemic than encouraging mandatory vaccinations? We can’t think of one. Expect severe blowback **

MedicalExpress.com report

 

Photo by CDC on Unsplash

EMA: If you have these symptoms after vaccination with AstraZeneca #coronavirus serum seek medical help immediately

“Wheezing, chest or stomach pain, swelling or coldness in an arm or leg, severe headache or worsening or blurred vision after vaccination, persistent bleeding, small multiple bruises, reddish or purplish spots or blisters of blood under the skin” – if you have these symptoms after vaccination against Covid with AstraZeneca serum seek medical help immediately and report that you have recently been vaccinated.

Il Giorno report

 

Image by Usman Yousaf from Pixabay

EMA: Anaphylaxis and hypersensitivity reactions should be included in the list of possible side effects of the Astrazeneca vaccine

European Medicines Agency (EMA), the corona vaccine from the manufacturer Astra-Zeneca can cause severe allergic reactions. Anaphylaxis and hypersensitivity reactions should be included in the list of possible side effects of the vaccine citing , the EMA said on Friday, several such cases in the UK.

FAZ.net report

 

Image by torstensimon from Pixabay

AstraZeneca halves #coronavirus vaccine delivery to the EU – export restrictions to blame

The European Commission received the message from AstraZeneca on Thursday afternoon (11 March 2021). According to Sweden’s vaccination coordinator Richard Bergström, it is export restrictions and not production capacity that are behind it.

Astra Zeneca has really made an effort to find volumes to live up to the contract. 75 million doses would come from the United States, the United Kingdom and to some extent from India in the second quarter. Now we have just been told that we will not get rid of these doses, says Richard Bergström to TV4.

The USA and India, where AstraZeneca’s has production, have introduced export bans to ensure that they themselves get enough vaccine. The fact that the vaccine cannot be delivered from the UK has contractual reasons.

Dagens Nyheter report

 

Image by torstensimon from Pixabay

Co-infection with 2 distinct #sarscov2 lineages reported in a patient in Portugal

“The patient had co-infection by two SARS-CoV-2 lineages, which were affiliated in distinct clades and diverging by six variants. The 20A lineage was absolute at the diagnosis (shared with the patient’s mother), but nine days later, the 20B lineage had 3% frequency, and two months later, the 20B lineage had 100% frequency”

https://pubmed.ncbi.nlm.nih.gov/33540596/

 

Image by sungmin cho from Pixabay