Delta 4+ variant: Complete vaccine escape & enhanced infectivity with Pfizer vaccine

B.1.617.2, Coronavirus, Delta, E484K, Infection, K417N, Mutation, N439K, N501Y, Pfizer/Biontech, Vaccine, Vaccine Breakthrough, Variants

“Here we suggest an evolutionary pathway by which the Delta variant could achieve complete escape from vaccine-induced immunity”.   Although Pfizer-BioNTech BNT162b2-immune sera neutralized the Delta variant, when four common mutations were introduced into the receptor binding domain (RBD) of the Delta variant (Delta 4+), some BNT162b2-immune sera lost neutralizing activity and enhanced the infectivity.

Unique mutations in the Delta NTD were involved in the enhanced infectivity by the BNT162b2-immune sera. Sera of mice immunized by Delta spike, but not wild-type spike, consistently neutralized the Delta 4+ variant without enhancing infectivity.

The 4 key mutations inserted were K417N, N439K, E484K and N501Y.


Preprint: The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines 



So what is Plan B if the vaccines fail?


** This post was originally published on September 18, 2021 **