In this study, we reported the emergence and spread of the novel B.1.621 lineage of SARS-CoV-2, a new VOI with the insertion 146N and several amino acid substitutions in the Spike protein (T95I,Y144T, Y145S, R346K, E484K, N501Y and P681H). Although B.1.621 does not meet all of the VOC classification criteria so far, the set of mutations gathered the Spike protein could confer a synergistic impact on attributes such as reduction of vaccine-induced protection from severe disease, increased transmission and disease severity
“There is no new hybrid variant in Vietnam at this moment based on WHO definition,” Kidong Park, the WHO representative in Vietnam, told Nikkei Asia on Wednesday. “The variant detected is Delta variant (B.1.617.2), with additional mutations, and needs more observation. We need to monitor during next couple of weeks,”
“This is within the existing [Delta] variant. It is an additional mutation” Park explained, adding “as for now, there is no alarming alert from WHO. Park also stressed the Delta variant is dangerous as it is highly contagious and spreads very quickly.
“Here we present a case of prolonged infection of greater than 6 months with shedding of high titer SARS-CoV-2 in an individual with advanced HIV and antiretroviral treatment failure. …Through whole genome sequencing at multiple time-points, we demonstrate the early emergence of the E484K substitution associated with escape from neutralizing antibodies, followed by other escape mutations and the N501Y substitution found in most variants of concern.”
Vietnam has detected a coronavirus hybrid variant with characteristics from the existing B16172 Delta variant and B117 Alpha variant, the Ministry of Health announced Saturday. Minister Nguyen Thanh Long said a new coronavirus variant has recently been detected in Vietnam with characteristics from both the Alpha and the Delta variants. More specifically, it is a Delta variant B.1.617.2 with mutations that originally belong to the Alpha variant B.1.1.7.
Laboratory cultures of the new variant, which is much more transmissible than the previously known types, revealed that the virus replicated itself very quickly, explaining why so many new cases appeared in different locations in a short period, Long was quoted as saying.
According to the Central Institute of Hygiene and Epidemiology, the results of viral gene sequencing of 32 Covid-19 patient samples, detected 4 samples infected with the Delta B16172 strain but carrying a gene mutation of the Alpha B117 strain.
“We found that there is a Y144 deletion mutation on the S protein of the virus B.1.617.2 (first detected in India). This mutation is similar to the mutation detected on variant B.1.1.7 (first detected in the UK)”, Professor Le Thi Quynh Mai, Deputy Director of the Central Institute of Hygiene and Epidemiology, said on the evening of May 29.
Up to now, Vietnam has recorded a total of 7 strains of nCoV, including: B.1.222, B.1.619, D614G, B.1.1.7 (Alpha variant), B.1.351, A.23.1 and B.1.617.2 (Delta variant).