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Lancet: Where is the next SARS-CoV-2 variant of concern?

Coronavirus, Evolution, Health, Healthcare, Hospitalization, Immunocompromised, Infection, Reservoir, Transmission, Treatment

“Curing COVID-19 infections in immunocompromised individuals is of crucial importance.”…

Immunocompromised patients, such as those infected with HIV or recipients of organ transplants, can have difficulty eliminating SARS-CoV-2 infections. Preliminary data suggest that infections often persist for many months with viruses acquiring new mutations over time as they presumably evade immune-mediated neutralisation and hone their ability to infect human cells.

The possibility of SARS-CoV-2 evolving resistance to existing therapies during such infections is real. Hence, curing COVID-19 infections in immunocompromised individuals is of crucial importance as it is possible that an existing patient might harbour the next variant, a highly transmissible new variant of concern that challenges immunity and existing therapeutics.

Full correspondence at The Lancet

Signatories: John J Dennehy, Ravindra K Gupta, William P Hanage, Marc C Johnson, Thomas P Peacock

 

 

Spillover of new BA.1 sublineage from persistently infected COVID patient into the community

 

 

 

Image by Andrew Martin from Pixabay