“Curing COVID-19 infections in immunocompromised individuals is of crucial importance.”…
Immunocompromised patients, such as those infected with HIV or recipients of organ transplants, can have difficulty eliminating SARS-CoV-2 infections. Preliminary data suggest that infections often persist for many months with viruses acquiring new mutations over time as they presumably evade immune-mediated neutralisation and hone their ability to infect human cells.
The possibility of SARS-CoV-2 evolving resistance to existing therapies during such infections is real. Hence, curing COVID-19 infections in immunocompromised individuals is of crucial importance as it is possible that an existing patient might harbour the next variant, a highly transmissible new variant of concern that challenges immunity and existing therapeutics.
Signatories: John J Dennehy, Ravindra K Gupta, William P Hanage, Marc C Johnson, Thomas P Peacock