Preprint: Omicron a recombination between BA.1 and B.35 lineages

B.35, Coronavirus, Infection, Omicron, Origins, Recombination, Transmission, Variants

Here, we show that Omicron lineage SARS-CoV-2 is characterized by the feature of chimera.

It was generated by genomic recombination of two early PANGO lineages of SARS-CoV-2. In the recombination event, strains with medium or high circulating intensity like SARS-CoV-2/human/USA/COR-21-434196/2021 belonging to PANGO lineage BA.1 provided the fundamental genome and served as the major parents, while the rare lineage strains like SARS-CoV-2/human/IRN/Ir-3/2019 belonging to B.35, as the minor parents, hybridized their genomic fractions into the major genomes at position 21593-23118nt.

ResearchSquare preprint: Omicron: a chimera of two early SARS-CoV-2 lineages


Something that would be very unlikely to happen in an immunocompromised patient and remain hidden for over a year…


Preprint: Evidence for a mouse origin of Omicron


** This post was originally published on February 3, 2022 **