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Two #coronavirus variants have merged into heavily mutated strain. #B117 meets #B1429

B.1.1.7, Coronavirus, Health, L452R, Mutation, Recombination, Science, Variants

Two variants of the SARS-CoV-2 coronavirus that causes covid-19 have combined their genomes to form a heavily mutated hybrid version of the virus. The “recombination” event was discovered in a virus sample in California, provoking warnings that we may be poised to enter a new phase of the pandemic.

The hybrid virus is the result of recombination of the highly transmissible B.1.1.7 variant discovered in the UK and the B.1.429 variant that originated in California and which may be responsible for a recent wave of cases in Los Angeles because it carries a mutation making it resistant to some antibodies.

The implications of the finding aren’t yet clear because very little is known about the recombinant’s biology. However, it does carry a mutation from B.1.1.7, called Δ69/70, which makes the UK virus more transmissible, and another from B.1.429, called L452R, which can confer resistance to antibodies.

Newscientist Article


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