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Monkeypox vaccine MVA repurposed for Covid-19

Coronavirus, Health, Mice, MVA Monkeypox, Testing, Transmission, Treatment, Vaccine

A new comparison study in PNAS from NIAID intramural scientists clearly shows that for SARS-CoV-2, nasal vaccination – particularly in two doses – has clear advantages over muscular delivery in laboratory mice. The vaccine tested uses an old immune-activation concept: modified vaccinia virus Ankara (MVA), which is a licensed smallpox and monkeypox vaccine, and is being actively pursued as a vector, or carrier, to deliver a viral protein for other infectious diseases. For this vaccine candidate, the MVA vector delivers the spike protein of SARS-CoV-2, which sits on the surface of the virus, to spur an immune response.

NIAID Mouse Study Shows Benefits of COVID-19 Nasal Vaccine vs. Intramuscular

PNAS preprint: Intranasal inoculation of an MVA-based vaccine induces IgA and protects the respiratory tract of hACE2 mice from SARS-CoV-2 infection

 

 

Preprint: Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage

 

 

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