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Preprint: Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage

Animals, Coronavirus, Infection, Preprint, Side Effects, Transmission, Vaccine

We hypothesize that SARS-CoV-2 spike (S) protein is sufficient to cause olfactory damage and olfactory dysfunction.

Using an adult zebrafish model, we report that intranasally delivered SARS-CoV-2 S RBD mostly binds to the non-sensory epithelium of the olfactory organ and causes severe olfactory histopathology characterized by loss of cilia, hemorrhages and edema.

Combined, our results demonstrate that intranasal SARS-CoV-2 S RBD is sufficient to cause structural and functional damage to the zebrafish olfactory system. These findings may have implications for intranasally delivered vaccines against SARS-CoV-2.

Preprint: Intranasal delivery of SARS-CoV-2 Spike protein is sufficient to cause olfactory damage, inflammation and olfactory dysfunction in zebrafish

 

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Photo by David Clode on Unsplash