NeoCoV – the closest MERS-CoV relative yet discovered in bats

Animals, Asia, China, Coronavirus, Omicron, Transmission, Zoonosis

In this study, we unexpectedly found that NeoCoV and its close relative, PDF-2180-CoV, can efficiently use some types of bat Angiotensin-converting enzyme 2 (ACE2) and, less favorably, human ACE2 for entry.   NeoCoV efficiently infects human ACE2 expressing cells after a T510F mutation on the receptor-binding motif (RBM).

Considering the extensive mutations in the RBD regions of the SARS-CoV-2 variants, especially the heavily mutated Omicron variant, these viruses may hold a latent potential to infect humans through further adaptation via antigenic drift. It is also very likely that their relatives with human emergence potential are circulating somewhere in nature.

Preprint: Close relatives of MERS-CoV in bats use ACE2 as their functional receptors (PDF download)




Image by Marcel Langthim from Pixabay

** This post was originally published on January 28, 2022 **