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Monkeypox: Prolonged upper respiratory tract viral DNA shedding

Canada, Genome, Health, Infection, Monkeypox, PCR, Preprint, Quarantine, Quebec, Research, Testing, Transmission

“Notable disease features included viraemia, prolonged monkeypox virus DNA detection in upper respiratory tract swabs, reactive low mood, and one patient had a monkeypox virus PCR-positive deep tissue abscess”

“We reviewed all cases since the inception of the HCID (airborne) network between Aug 15, 2018, and Sept 10, 2021, identifying seven patients. Of the seven patients, four were men and three were women. Three acquired monkeypox in the UK: one patient was a health-care worker who acquired the virus nosocomially, and one patient who acquired the virus abroad transmitted it to an adult and child within their household cluster. Notable disease features included viraemia, prolonged monkeypox virus DNA detection in upper respiratory tract swabs, reactive low mood, and one patient had a monkeypox virus PCR-positive deep tissue abscess. Five patients spent more than 3 weeks (range 22–39 days) in isolation due to prolonged PCR positivity.

Prolonged upper respiratory tract viral DNA shedding after skin lesion resolution challenged current infection prevention and control guidance. There is an urgent need for prospective studies of antivirals for this disease.

Lancet report:  Clinical features and management of human monkeypox: a retrospective observational study in the UK

 


 

 


 
 


 
 

Preprint: Monkeypox genetic divergence and first signs of microevolution

 

 

 

 

Image by Okan Caliskan from Pixabay