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SARS-CoV-2 can infect and kill different immunity cell types independently of ACE2

Coronavirus, Deaths, Health, Healthcare, Hospitalization, Infection, Side Effects, Transmission

In one of the most disturbing preprints we have seen during the entire pandemic, researchers outline the damage that SARS-CoV-2 can do to key components of the human immune system, independently of ACE2.

Highlights:

  • SARS-CoV-2 antigens were present inside the T lymphocytes, the virus could directly infect T cells
  • Lung tissue contained high levels of T lymphocytes, many T lymphocytes tested positive for SARS-CoV-2 proteins
  • T lymphocytes from SARS-CoV-2 patients displayed nearly ten times the number of apoptotic cells than healthy individuals
  • SARS-CoV-2 infection of T cells occurs independently from the ACE2 receptors
  • After SARS-CoV-2 infection “CD4+ and CD8+ T lymphocytes almost declined to zero in some patients
  • Both Jurkat and M4 cell lines were infected in vitro
  • SARS-CoV-2 can infect T lymphocytes and induce pronounced programmed apoptosis, or cell death

 

Preprint:  ACE2-independent infection of T lymphocytes by SARS-CoV-2

 

H/t Gunhild Alvik Nyborg

 

 

 

See also: William Haseltine’s review at Forbes.com: SARS-CoV-2 Actively Infects And Kills Lymphoid Cells

 

 

Image by NIAID/NIH, Public domain, via Wikimedia Commons