Preprint: C.37 Lambda variant exhibits higher infectivity and immune resistance

America, Argentina, C-37, Chile, Coronavirus, Genome, Health, Infection, Lambda, Peru, Science, Testing, Transmission, Vaccine, Vaccine Breakthrough

“In this study, we demonstrated that three mutations, the RSYLTPGD246-253N, L452Q and F490S mutations, respectively confer resistance to the vaccine-induced antiviral immunity. Additionally, the T76I and L452Q mutations contribute to enhanced viral infectivity. Our data suggest that there are at least two virological features on the Lambda variant: increasing viral infectivity (by the T76I and L452Q mutations) and exhibiting resistance to antiviral immunity (by the RSYLTPGD246-253N, L452Q and F490S mutations).”

BiorXiv preprint: SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance

 

 

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