Africa: Tanzania/Angola #coronavirus variant carries E484K & H655Y mutations

Forbes are carrying an interesting about the recently discovered coronavirus variant found in Tanzania, Africa in travellers arriving from Angola.  The variant is from “From An Entirely New Branch Of SARS-CoV-2”, and carries Spike mutations E484K, P681H, T478R, Q957H, H655Y, D215G, D80Y. L210N, W258L, R246I.  “An additional 18 amino acid changes occur in proteins outside the spike protein. These include 14 in the orf1ab proteins that specify the replication complex. “

“This is a remarkable illustration of convergent evolution,” say’s Forbes

Forbes article: New Tanzanian Variant Detected In Angola From An Entirely New Branch Of SARS-CoV-2

 

 

 

A novel variant of interest of SARS-CoV-2 with multiple spike mutations detected through travel surveillance [Angola/Tanzania]

“We detected a new VOI in three incoming travelers from Tanzania who were tested together at the airport in mid-February. The three genomes from these passengers were almost identical and presented highly divergent sequences within the A lineage. The GISAID database contains nine other sequences reported to be sampled from cases involving travel from Tanzania, two of which are basal to the three sampled in Angola”

This new VOI, temporarily designated A.VOI.V2, has 31 amino acid substitutions (11 in spike) and three deletions (all in spike) (Figure 1C & 1D). The spike mutations include three substitutions in the receptor-binding domain (R346K, T478R and E484K); five substitutions and three deletions in the N-terminal domain, some of which are within the antigenic supersite (Y144?, R246M, SYL247-249? and W258L)4; and two substitutions adjacent to the S1/S2 cleavage site (H655Y and P681H). Several of these mutations are present in other VOCs/VOIs and are evolving under positive selection.

Krisp.org.za report

See also:

New #coronavirus variant in Tanzania has “10 more mutations than have been found on any other version”

 

Image by jorono from Pixabay

New #coronavirus variant in Tanzania has “10 more mutations than have been found on any other version”

The most mutated variant of the coronavirus yet was found in travellers from Tanzania. A report submitted to the World Health Organization and regional bodies shows the strain has 10 more mutations than found on any other version, according to Tulio de Oliveira, director of Krisp, a scientific institute that carries out genetic testing for 10 African nations.

Krisp, which discovered a new strain in South Africa last year that propelled a resurgence of infections in the country, found the new variant in travellers arriving in Angola from Tanzania.

Bloomberg report

See also: A novel variant of interest of SARS-CoV-2 with multiple spike mutations detected through travel surveillance [Angola/Tanzania]

 

Image by ramalholore from Pixabay