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A coronavirus variant with T205I and D399N mutations that affects antigen test performance

Antigen, Coronavirus, Health, Infection, Mutation, Science, Testing, Transmission

“While determining the analytical sensitivity of the Quidel Sofia SARS 24 Antigen FIA test (Sofia 2), we uncovered a high viral load specimen that repeatedly tested negative by this antigen test. Whole genome sequencing of the specimen uncovered two mutations, T205I and D399N, present in the nucleocapsid protein of the isolate. All six SARS-CoV-2 positive clinical specimens available in our laboratory with a D399N nucleocapsid mutation and C T < 31 were not detected by the Sofia 2 but detected by the Abbott BinaxNOW COVID-19 Ag Card, while clinical specimens with the T205I mutation were detected by both assays”

Preprint: A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance 


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