SARS-CoV-2 501YV2 escapes neutralization by South African COVID-19 donor plasma
SARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma
“SARS-CoV-2 501Y.V2, a novel lineage of the coronavirus causing COVID-19, contains multiple mutations within two immunodominant domains of the spike protein. Here we show that this lineage exhibits complete escape from three classes of therapeutically relevant monoclonal antibodies. Furthermore 501Y.V2 shows substantial or complete escape from neutralizing antibodies in COVID-19 convalescent plasma. These data highlight the prospect of reinfection with antigenically distinct variants and may foreshadow reduced efficacy of current spike-based vaccines.”
https://www.biorxiv.org/content/10.1101/2021.01.18.427166v1
Image by Pete Linforth from Pixabay
** This post was originally published on January 27, 2021 **