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UKHSA: Hepatitis in kids – revised hypotheses include new SARS-CoV-2 variant

Children, Coronavirus, Covid-19 Censorship, Deaths, England, Europe, Health, Hepatitis, Hospitalization, Infection, London, Northern Ireland, Scotland, Transmission, UK, Wales

THE UKHSA have released a new technical briefing today outlining their latest hypotheses for the outbreak of acute hepatitis in kids across Britain.

The following hypotheses are all being actively tested by the investigations in process.

There are increased paediatric acute non-A-E hepatitis presentations due to:

1. A normal adenovirus infection, due to one of:

a. Abnormal susceptibility or host response which allows adenovirus infection to progress more frequently to hepatitis (whether direct or immunopathological), for example from lack of exposure during the coronavirus (COVID-19) pandemic.

b. An exceptionally large wave of normal adenovirus infections, causing a very rare or under-recognised complication to present more frequently.

c. Abnormal susceptibility or host response to adenovirus due to priming by a prior infection with SARS-CoV-2 (including Omicron restricted) or another infection.

d. Abnormal susceptibility or host response to adenovirus due to a coinfection with SARS-CoV-2 or another infection.

e. Abnormal susceptibility or host response to adenovirus due to a toxin, drug or environmental exposure.

2. A novel variant adenovirus, with or without a contribution from a cofactor as listed above.

3. A post-infectious SARS-CoV-2 syndrome (including an Omicron restricted effect).

4. A drug, toxin or environmental exposure.

5. A novel pathogen either acting alone or as a coinfection.

6. A new variant of SARS-CoV-2.

 

The full technical briefing is republished below, or it can be downloaded from here

 

acute-hepatitis-technical-briefing-2

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Feb 2022 Research: Severe hepatitis in pediatric COVID-19 – *7 UPDATES*

 

 

Image by 4144132 from Pixabay