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Preprint: Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

Coronavirus, Health, Hospitalization, Infection, Mental Heath, Mice, Preprint, Research, Symptoms

“These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.”

Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.

Preprint  paragraph headings:

Mild respiratory COVID causes prominent neuroinflammation

White matter microglial reactivity in humans after Covid

Single cell transcriptomic profiling of microglia after mild respiratory COVID in mice

Mild respiratory COVID impairs hippocampal neurogenesis

Elevated CCL11 levels in humans with cognitive symptoms following COVID

CCL11 causes specific reactivity of hippocampal microglia and impairs neurogenesis 

Mild respiratory COVID impairs myelinating oligodendrocytes

 

Preprint: Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

 

See also:

Longitudinal study describes short- and long-term neurological symptoms of SARS-CoV-2 infection; identifies new subgroup with advanced symptoms

COVID-19 on the brain: Neurological symptoms persist in majority of long-haulers

 

 

Preprint: Autopsies reveal Covid-19 brain damage

 

 

 

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