For children 5-11, VE against cases declined from 65% to 12% by 28-34 days. In the Omicron era, the effectiveness against cases of BNT162b2 declined rapidly for children, particularly those 5-11 years.
However, vaccination of children 5-11 years was protective against severe disease and is recommended. These results highlight the potential need to study alternative vaccine dosing for children and the continued importance layered protections, including mask wearing, to prevent infection and transmission.
