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Preprint: Rates of COVID-19 among unvaccinated adults with prior infection

Coronavirus, Deaths, Health, Healthcare, Hospitalization, Infection, PCR, Reinfection, Testing, Transmission, Vaccine, Vaccine Breakthrough, Vaccine Waning

Prior COVID-19 (in the unvaccinated) was associated with protection of 85% against any recurrent COVID-19, 88% against hospitalization for COVID-19, and 83% against COVID-19 not requiring hospitalization. Protection remained stable over the study period with no attenuation up to 9 months from initial infection.

This cohort study used data from patients tested for SARS-CoV-2 at 1300 sites of care in 6 western US states in the Providence health care system between October 1, 2020, and November 21, 2021. Patients who were unvaccinated for and had symptoms consistent with COVID-19 at the time of testing were included. Beginning 90 days after their initial SARS-CoV-2 nucleic acid amplification test (NAAT), patients were monitored for subsequent COVID-19, as determined by a positive SARS-CoV-2 NAAT result in the presence of symptoms.

We identified 24 043 cases and 97 572 controls; 2762 controls (2.8%) developed COVID-19 compared with 98 cases (0.4%) (Table). The Figure shows disease-free survival among cases and controls. In the survival model, the HR among cases for developing COVID-19 was 0.15 (95% CI, 0.13-0.18); for hospitalization for COVID-19, 0.12 (95% CI, 0.08-0.18); and for COVID-19 not requiring hospitalization, 0.17 (95% CI, 0.13-0.21). Prior COVID-19 was associated with protection of 85% against any recurrent COVID-19, 88% against hospitalization for COVID-19, and 83% against COVID-19 not requiring hospitalization. Protection remained stable over the study period with no attenuation up to 9 months from initial infection.

Jamanetwork preprint: Rates of COVID-19 Among Unvaccinated Adults With Prior COVID-19

 

 

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Image by Helena Jankovičová Kováčová from Pixabay