Here, we report a case of persistent SARS-CoV-2 infection in an immunocompromised patient with chronic lymphocytic leukemia (CLL), asymptomatically carrying infectious SARS-CoV-2 at day 197 post diagnosis. Viral sequencing showed accumulation of mutations over time and indicated major changes in the spike protein, temporally associated with convalescent plasma treatment… Virus eradication is thus far unsuccessful, as weekly performed RT-PCR tests remain positive for SARS-CoV-2, with the last sample acquired on day 333 just prior to submission of this report.
