Tag: human
China: Zhengli & Daszak – Human-animal interactions and bat coronavirus spillover potential among rural residents in Southern China
Zhengli & Daszak study, September 2019 – “We conducted a cross-sectional study in the districts of Yunnan, Guangxi, and Guangdong, China… Serological testing of serum samples from 1,497 local residents revealed that 9 individuals (0.6%) in four study sites were positive for bat coronaviruses, indicating exposure at some point in their life to bat-borne SARSr-CoVs (n=7, Yunnan), HKU10-CoV (n=2, Guangxi), or other coronaviruses that are phylogenetically closely related to these. More...
India: Shi Zhengli, October 2019 – Filovirus antibodies in humans and bats imply zoonotic spillover
India, October 2019, Zhengli Shi et al: “We present evidence for prior exposure of bat harvesters and two resident fruit bat species to filovirus surface glycoproteins… Our results indicate circulation of several filoviruses in bats and the possibility for filovirus transmission from bats to humans. More...
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 coronavirus
In this work, we reconstruct the evolutionary events that have accompanied the emergence of SARS-CoV-2, with a special emphasis on the RBD and its adaptation for binding to its receptor, human ACE2 (hACE2). More...
Walter Reed coronavirus study: “We found moderate evidence for 8 SARS-CoV-2 recombination events, two of which involved the spike gene”
We undertook recombination analyses of 158,118 public seasonal hCoV, SARS-CoV-1, SARS-CoV-2 and MERS-CoV genome sequences using the RDP4 software. More...
Mutations arising in SARS-CoV-2 spike on sustained human-to-human transmission and human-to-animal passage
“Spike mutations have also occurred during interspecies transfers of SARS-CoV-2 from humans to animals, both during establishment of experimental models of COVID-19 and as an unintended consequence of human interactions with domestic, curated and commercial animals.” More...