Preprint: SARS-CoV-2 invades the brain and activates an Alzheimers-like program

Children, Coronavirus, Health, Healthcare, Hospitalization, Infection, Mental Heath, Reinfection, Side Effects, Symptoms

Here, we show that SARS-CoV-2 invades the brains of five patients with COVID-19 and Alzheimers, autism, frontotemporal dementia or no underlying condition by infecting neurons and other cells in the cortex.

SARS-CoV-2 induces or enhances Alzheimers-like neuropathology with manifestations of beta-amyloid aggregation and plaque formation, tauopathy, neuroinflammation and cell death.

A gene signature defined as an Alzheimers infectious etiology is identified through SARS-CoV-2 infection, and silencing the top three downregulated genes in human primary neurons recapitulates the neurodegenerative phenotypes of SARS-CoV-2. Thus, SARS-CoV-2 invades the brain and activates an Alzheimers-like program.


Preprint: SARS-CoV-2 invades cognitive centers of the brain and induces Alzheimer’s-like neuropathology






Photo by Milad Fakurian on Unsplash

** This post was originally published on February 2, 2022 **