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Preprint: Enhanced Fusogenicity of BA.4, BA.5 and BA.2.12.1

Asia, Australia, BA.2, BA.2.12.1, BA.4, BA.5, Coronavirus, Europe, Evolution, Genome, Infection, Moderna, Pfizer/Biontech, Testing, Transmission, USA, Vaccine

“We found that the new Omicron subvariants BA.4/5 and BA.2.12.1 were more resistant to neutralization by mRNA-vaccinated and boosted health care worker sera and Omicron-BA.1-wave patient sera than were the BA.1 and BA.2 variants.”

Interestingly, Delta-wave patient sera neutralized more efficiently against not only Delta but also BA.4/5 and BA.2.12.1 variants that also contain substitutions at position L452, similar to Delta. The BA.4/5 and BA.2.12.1 variants also exhibited higher fusogenicity, and increased spike processing, dependent on the L452 substitution. These results highlight the key role of the L452R and L452Q mutations in BA.4/5 and BA.2.12.1 subvariants.

Preprint: Differential Evasion of Delta and Omicron Immunity and Enhanced Fusogenicity of SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants



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Image by Ils Verhoeven from Pixabay