FT: “the vaccines send the DNA gene sequences of the spike protein into the cell … Once inside the cell nucleus, certain parts of the spike protein splice, or split apart“
During the last months many countries have started the immunization of millions of people by using vector-based vaccines. Unfortunately, severe side effects became overt during these vaccination campaigns: cerebral venous sinus thromboses (CVST), absolutely rare under normal life conditions, were found as a severe side effect that occured 4-14 days after first vaccinations. Besides CVST, Splanchnic Vein Thrombosis (SVT) was also observed. This type of adverse event has not been observed in the clinical studies of AstraZeneca, and therefore led immediately to a halt in vaccinations in several european countries.
These events were mostly associated with thrombocytopenia, and thus, similar to the well-known Heparin-induced thrombocytopenia (HIT). Meanwhile, scientists have proposed a mechanism to explain this vaccine-induced thrombocytopenia. However, they do not provide a satisfactory explanation for the late thromboembolic events. Here, we present data that may explain these severe side effects which have been attributed to adenoviral vaccines.
According to our results, transcription of wildtype and codon-optimized Spike open reading frames enables alternative splice events that lead to C-terminal truncated, soluble Spike protein variants. These soluble Spike variants may initiate severe side effects when binding to ACE2-expressing endothelial cells in blood vessels. In analogy to the thromboembolic events caused by Spike protein encoded by the SARS-CoV-2 virus, we termed the underlying disease mechanism the “Vaccine-Induced Covid-19 Mimicry” syndrome (VIC19M syndrome).
Researchgate paper “Vaccine-Induced Covid-19 Mimicry Syndrome: Splice reactions within the SARS-CoV-2 Spike open reading frame result in Spike protein variants that may cause thromboembolic events in patients immunized with vector-based vaccines”.
FT Article “Scientists claim to have solved Covid vaccine blood-clot puzzle”
Princess Michael of Kent is being treated for blood clots after receiving two doses of the Oxford/AstraZeneca vaccine – although no link has been established. Sources close to the 76-year-old said concerns for her health emerged after she received her second jab earlier this year. The royal has been recovering at home for almost a month.
‘The Princess has been unwell and has sought medical attention,’ a source told the Sun on Sunday. ‘It has been a worrying time for those around her. It has been difficult for those close to her to see her suffering. She’s really been through it.’
The AstraZeneca vaccine has come under scrutiny in Europe after being linked to a very small number of blood clot cases. A scientific review by UK medical regulator MHRA concluded in April that evidence of a link between the vaccine and rare blood clots ‘is stronger but more work is still needed’.
The risk of thrombosis at 11 excess events per 100 000 vaccinations are higher than estimated by the European Medicines Agency. The EMA estimates the risk of thrombosis to be between 1 and 2 per 100 000 people, depending on age. Among the venous thromboembolic events, the most notable was cerebral venous thrombosis, which was about 20 times more common after the Oxford-AstraZeneca vaccine than expected with an excess risk of 2.5 per 100 000 vaccinations. Venous thromboembolic events were more common in women than in men and were also more common in people aged 18-44 than in those aged 45-65. Thrombocytopenia and bleeding were mildly increased after vaccination, but not significantly.
Study Paper here: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S in Denmark and Norway: population based cohort study
“I can confirm that we have received another report of a suspected death linked to vaccination last week,” writes Veronica Arthurson, unit manager at the Medical Products Agency in a text message to SVT. The woman in her 70s was completely healthy when she was vaccinated with Astra Zeneca’s vaccine, according to relatives. A few days later, she got the unusual side effects – blood clots and low levels of platelets – which have been the focus of the EU Medicines Agency’s review of the vaccine, according to SVT.
FDA and CDC have recommended lifting the pause on Johnson & Johnson (Janssen) COVID-19 Vaccines in the USA.
On April 13, the FDA and CDC announced that, out of more than 6.8 million doses administered, six reports of a rare and severe type of blood clot combined with low blood platelet levels occurring in people after receiving the Janssen COVID-19 Vaccine had been reported to VAERS. In these cases, a type of blood clot called cerebral venous sinus thrombosis (CVST) was seen in combination with low levels of blood platelets (thrombocytopenia).
Today, the agencies can confirm that a total of 15 cases of TTS have been reported including the original six reported cases. All of these cases occurred in women between the ages of 18 and 59, with a median age of 37 years. Reports indicated symptom onset between 6 and 15 days after vaccination.
The Spanish Health Department is investigating the death of a corporal, aged 35, assigned to the Infantry Regiment América 66 de Cazadores de Montaña, based in the Aizoáin barracks, Navarra, after suffering a “cerebral sinus thrombosis with thrombocytopenia and cerebral hemorrhage”, 17 days after receiving the AstraZeneca vaccine. The military man died this morning at the University Clinic of Navarra.
The corporal, married and expecting a child, was vaccinated with AstraZeneca on the afternoon of April 7 in his own unit. The Spanish Troop and Sailor Association (ATME) explained that in the following days he suffered “severe headaches and acute discomfort”, which forced him to go to the barracks first aid service and then to the emergency room of a health center from Pamplona. On the night of this last Wednesday, April 21, the corporal suffered a faint while he was at his home, according to the Army, to which America 66 belongs.
Update: “This Friday, the Pharmacovigilance Center of the Health Department of the Government of Navarra has received a notification of a “adverse event with fatal outcome” of a person who had been vaccinated with Vaxzevria (AstraZeneca) on April 7 against Covid-19. Despite the fact that the Provincial Government has reported that he had died after suffering a “cerebral sinus thrombosis with thrombocytopenia and cerebral hemorrhage”, the affected person has not died and is in a situation of brain death.”
The Australian Therapeutic Goods Administration is investigating three new cases of a rare blood clot syndrome “likely” linked to the AstraZeneca vaccine. The cases are a 35-year-old woman, a 49-year-old man and an 80-year-old man. It is the first time the syndrome has been reported in a person over 50 in Australia. The TGA said in a statement all cases were likely linked to the AstraZeneca vaccine. The TGA said one patient developed symptoms “unusually late” – 26 days after the vaccination.
The risk of a serious blood clot from AstraZeneca jab has doubled in a fortnight, new data show. Cases have gone up from 79 to 168 and deaths from 19 to 32. The chance of having a clot following vaccination has gone from one in 250,000 to one in 126,582.
Seven people suffered from partial paralysis after receiving the Sinovac vaccine, a doctor from Chulalongkorn University said. Six of them were in Rayong and one at the Queen Savang Vadhana Memorial Hospital in Chon Buri’s Sri Racha district. Their conditions improved after doctors administered medication to dissolve blood clots.
The TGA’s Vaccine Safety Investigation Group (VSIG) met late today and concluded that a recently reported case of thrombosis (blood clots in the arteries and veins) with thrombocytopenia (low platelet count) is likely to be linked to vaccination. VSIG reviewed a report about a 48-year-old woman who was vaccinated in New South Wales and admitted to hospital with an extensive thromboembolic event and thrombocytopenia (TTS) four days after receiving the AstraZeneca COVID-19 Vaccine. Sadly,
this person Genene Norris died in hospital and we extend our sincerest condolences to her family.
RIP Genene Norris
Nine new cases of atypical thrombosis (clots) and two cases of coagulation disorders associated with AstraZeneca’s Covid-19 vaccine, with four additional deaths, occurred in France between April 2 and April 8, according to French health authorities. The nine new cases of rare thrombosis concern people who present “a profile different from that” of the cases declared previously, notes the ANSM. The age of the patients is “higher”: “It is about four women and five men, older (average age of 62 years) who presented more digestive thromboses.
Marie-Antoinette Sevestre-Pietri, French Society of Vascular Medicine President: “”In the long term, it will probably be necessary to do without adenovirus vaccines”
Australian Federal health authorities are investigating the death of a 48-year-old New South Wales woman who developed blood clots after receiving a COVID-19 vaccine. If it is confirmed the woman contracted blood clots linked to a COVID-19 vaccine, it would be the third such case in Australia since the rollout began.
Denmark has received the first claim for compensation for a death caused by a special type of blood clot, which the authorities link with the Astrazeneca vaccine. The patient compensation scheme has received a total of 29 compensation applications from citizens who have received the Astrazeneca vaccine. A further eight cases concern the Pfizer vaccine. There are no claims for Moderna.
This is stated by Patienterstatningen, which handles cases of compensation for citizens who are affected by serious side effects from e.g. medicines.
After her first vaccination with Astrazeneca, the 43-year-old nurse Tina Sylvester Rohrmann from Nyborg was hit by blood clots in her lungs. She is sure that there is a connection with the vaccine. The doctors at OUH in Svendborg think the same, she says. The Funen nurse fully supports vaccines. Just not the one from Astrazeneca.
Avisendanmark report (paywall)