New #coronavirus variant with #E484K, #N501Y & #P681H mutations found in the Philippines, designated PHL-B.1.1.28

Here, we describe the emergence of a new SARS-CoV-2 lineage, mainly from the Central Visayas region of the Philippines. This emergent variant is characterized by 13 lineage-defining mutations, including the co-occurrence of the E484K, N501Y, and P681H mutations at the spike protein region, as well as three additional radical amino acid replacements towards the C-terminal end of the said protein. A three-amino acid deletion at positions 141 to 143 (LGV141_143del) in the spike protein was likewise seen in a region preceding the 144Y deletion found in the B.1.1.7 variant. A single amino acid replacement, K2Q, at the N-terminus of ORF8 was also shared by all 33 samples sequenced.

Medrxiv paper  Genome sequencing and analysis of an emergent SARS-CoV-2 variant characterized by multiple spike protein mutations detected from the Central Visayas Region of the Philippines



 Image by TheDigitalWay from Pixabay


New Philippines #coronavirus variant has #484K and #501Y mutations

On Thursday, the Department of Health (DoH) in Central Visayas (The Philippines) confirmed that they have detected two mutations with “potential clinical significance” of SARS-CoV-2 that cause the disease.

The two mutations were identified as E484K and N501Y and they were detected from samples from Central Visayas.

The 484K mutation – which differs from its genetic sequence – is found in the South African variant of SARS-CoV-2, while the N501Y mutation is found in the UK coronavirus variant and is said to have a higher chance of infection. article