Preprint: Just three mutations for SARS-CoV-2 to escape from highly neutralizing convalescent plasma

Coronavirus, Evolution, Infection, Mutation, Transmission, Vaccine, Vaccine Breakthrough

“Only three mutations were sufficient to generate this escape variant.”  This work shows that, under strong immune pressure, SARS-CoV-2 can use mutations in both the N-terminal domain and the receptor-binding domain to escape potent polyclonal neutralizing responses. Indeed, after a long period under immune selective pressure, SARS-CoV-2 evolved to evade the immunity of a potent polyclonal serum from a COVID-19 convalescent donor. Only three mutations were sufficient to generate this escape variant. The new virus was resistant to 70% of the neutralizing antibodies tested and had a decreased susceptibility to all convalescent sera.

Preprint: SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma


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** This post was originally published on August 23, 2021 **