UK: Delta with K417N – the “mountaineers” variant – PHE #coronavirus Delta-AY.1 update

Of the 36 cases of Delta-AY.1 (mountaineers) variant, 27 cases were known to have a vaccination status within the National Immunisation Management System (NIMS). 

“Through routine scanning of variation in Delta a small number of sequences were detected which had acquired the spike protein mutation K417N. Information suggests that there are at least 2 separate clades of Delta with K417N. One clade is large and internationally distributed with PANGO lineage designation AY.1. A second clade found in sequences uploaded to GISAID from the USA. There is limited epidemiological information available at present.

International Epidemiology
As of 7 June 2021, 63 genomes of Delta with K417N have been identified on GISAID. from Canada (1) Germany (1), Russia (1), Nepal (2), Switzerland (4), India (6), Poland (9), Portugal (12), Japan (13), USA (14).

Epidemiology
There are currently 36 cases of Delta-AY.1 in England (35 confirmed sequencing and 1 probable genotyping) plus an additional 10 sequences which include some cases in other UK nations and some genomes for which case data is being sought. The first 5 cases were sequenced on 26 April 2021 and were contacts of travellers to Nepal and Turkey. All these cases were detected in the West Midlands. Cases have been detected in 6 different regions in England (Table 21, Figure 26). The majority of cases are in younger individuals, with 2 cases of age 60 or over (Figure 27). Out of the 36 cases, there were 11 travel associated cases (6 travellers and 5 cases amongst contacts of travellers). Twelve cases have no history of travel or contact with travellers. Countries of travel included red-list countries (Nepal and Turkey), amber-list countries (Malaysia) and green-list countries (Singapore).

Of the 36 cases, 27 cases were known to have a vaccination status within the National Immunisation Management System (NIMS), when linked on NHS number. Of these, 18 cases occurred in people who were not vaccinated, 2 cases in people who had received their first dose within 21 days of specimen date, 5 cases in people who had received their  first dose more than 21 days after specimen date. There was a total of 2 cases where there were more than 14 days between the second dose of vaccine and a positive specimen. No deaths have been recorded amongst the 36 cases.”

PHE download – SARS-CoV-2 variants of concern and variants under investigation in England  – Technical briefing 15 (PDF)

 

UK: The “mountaineers variant” – B.1.617.2 with K417N mutation

 

UK: “Everest climbers could have spread potentially more infectious and vaccine resistant’ variant

 

 

Image by Simon from Pixabay

UK: The “mountaineers variant” – B.1.617.2 with K417N mutation

The Delta variant with the K417N mutation, also known as the “Mountaineers” variant, has cropped up 14 times in Japan, and 13 of those samples were in travellers from Nepal – mostly climbers from Everest expeditions. At least 100 cases were reported at the Everest base camp, it is believed that the variant could have been spread by climbers ascending the mountain despite widespread national lockdowns across the globe.  Cases have also been identified in India, Japan, Portugal, and the UK.

According to Dr Jeff Barrett, director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute in the UK, at least one case has been found in the US.

DNAIndia.com report: Delta+K417N variant that affected at least 100 Everest climbers

 

The mountaineers variant B.1.617.2 + K417N has also been blamed for the axing of Portugal from the UK’s green travel list. See this report

 

UK: Delta with K417N – the “mountaineers” variant – PHE #coronavirus Delta-AY.1 update

 

UK: “Everest climbers could have spread potentially more infectious and vaccine resistant’ variant

 

Photo by Claire Nolan on Unsplash

UK: “Everest climbers could have spread potentially more infectious and vaccine resistant’ variant

So, more of a “Western mountaineers” variant then?

 

Daily Mail story “Everest climbers could have spread ‘potentially more infectious AND vaccine resistant’ Nepal Covid variant

 

UK: Grant Shapps – “there’s a sort of Nepal mutation of the so-called Indian variant which has been detected and we just don’t know the potential for that to be a vaccine-defeating mutation”

 

The “Nepal Variant” – does it exist or is it just racist fearmongering?

 

Photo by Mountain Magic Treks Pvt.Ltd on Unsplash