Tag: N501Y

Sars-Cov-2 lab variant bound 600 times more successfully to human cells than the original strain

The naturally selected mutations S477N, E484K, and N501Y of the Spike protein RBD, which show higher infectivity, were selected by yeast surface display affinity maturation already in the first round, giving rise to the South-African, E484K, N501Y, and British variants that bind ACE2 13 and 3.5-fold tighter than RBD-WT.  More...

Coronaheadsup.com Coronavirus, E484K, Health, Infection, Mutation, N501Y, Reinfection, Science, Treatment, Vaccine

Emergence and rapid spread of a new SARS-CoV-2 lineage with multiple spike mutations in South Africa

“Here, we describe a new SARS-CoV-2 lineage (501Y.V2) characterised by eight lineage-defining mutations in the spike protein, including three at important residues in the receptor-binding domain (K417N, E484K and N501Y) that may have functional significance.  More...

Coronaheadsup.com Africa, Coronavirus, E484K, Mutation, N501Y, Reinfection, Science, South Africa, Vaccine

Mutations arising in SARS-CoV-2 spike on sustained human-to-human transmission and human-to-animal passage

“Spike mutations have also occurred during interspecies transfers of SARS-CoV-2 from humans to animals, both during establishment of experimental models of COVID-19 and as an unintended consequence of human interactions with domestic, curated and commercial animals.”  More...

Coronaheadsup.com Animals, Coronavirus, Health, Mutation, Reinfection, Science, Vaccine

Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England

“..the increase in transmissibility is likely to lead to a large increase in incidence, with COVID-19 hospitalisations and deaths projected to reach higher levels in 2021 than were observed in 2020, even if regional tiered restrictions implemented before 19 December are maintained”.  More...

Coronaheadsup.com Coronavirus, England, Europe, Health, Mutation, Northern Ireland, Reinfection, Science, Scotland, UK, Vaccine, Wales