New coronavirus variant with E484K, N501Y & P681H mutations found in the Philippines, designated PHL-B.1.1.28

Asia, B.1.1.28, Coronavirus, E484K, Health, Infection, Mutation, N501Y, P.3, PHL-B.1.1.28, Science, Testing, The Philippines, Vaccine, Variants

Here, we describe the emergence of a new SARS-CoV-2 lineage, mainly from the Central Visayas region of the Philippines. This emergent variant is characterized by 13 lineage-defining mutations, including the co-occurrence of the E484K, N501Y, and P681H mutations at the spike protein region, as well as three additional radical amino acid replacements towards the C-terminal end of the said protein. A three-amino acid deletion at positions 141 to 143 (LGV141_143del) in the spike protein was likewise seen in a region preceding the 144Y deletion found in the B.1.1.7 variant. A single amino acid replacement, K2Q, at the N-terminus of ORF8 was also shared by all 33 samples sequenced.

Medrxiv paper  Genome sequencing and analysis of an emergent SARS-CoV-2 variant characterized by multiple spike protein mutations detected from the Central Visayas Region of the Philippines



 Image by TheDigitalWay from Pixabay


** This post was originally published on March 5, 2021 **