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Genomics and epidemiology of a novel #SARSCoV2 lineage in Manaus, Brazil #P1 #coronavirus

America, Brazil, Coronavirus, E484K, Health, Infection, Mutation, P.1, Science, Testing

Through genome sequencing of viruses sampled in Manaus between November 2020 and January 2021, we identified the emergence and circulation of a novel SARS-CoV-2 variant of concern, lineage P.1, that acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor.

Molecular clock analysis shows that P.1 emergence occurred around early November 2020 and was preceded by a period of faster molecular evolution. Using a two-category dynamical model that integrates genomic and mortality data, we estimate that P.1 may be 1.4–2.2 times more transmissible and able to evade 25-61% of protective immunity elicited by previous infection with non-P.1 lineages.

Full Preprint Paper on Github (pdf file)

 

Image by Melisa Estefania from Pixabay