Tag: binding
Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2 coronavirus
In this work, we reconstruct the evolutionary events that have accompanied the emergence of SARS-CoV-2, with a special emphasis on the RBD and its adaptation for binding to its receptor, human ACE2 (hACE2). More...
The South African and Brazilian coronavirus variants can now infect mice
Here we show that unlike the initial virus, VOCs are able to infect common laboratory mice, replicating to high titers in the lungs. More...
Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil P1 coronavirus
Through genome sequencing of viruses sampled in Manaus between November 2020 and January 2021, we identified the emergence and circulation of a novel SARS-CoV-2 variant of concern, lineage P.1, that acquired 17 mutations, including a trio in the spike protein (K417T, E484K and N501Y) associated with increased binding to the human ACE2 receptor. More...
Sars-Cov-2 lab variant bound 600 times more successfully to human cells than the original strain
The naturally selected mutations S477N, E484K, and N501Y of the Spike protein RBD, which show higher infectivity, were selected by yeast surface display affinity maturation already in the first round, giving rise to the South-African, E484K, N501Y, and British variants that bind ACE2 13 and 3.5-fold tighter than RBD-WT. More...
Cambridge study: “Dog, cat, and cattle ACE2 receptors were identified as the strongest interactors with the SARS-CoV-2 spike protein”
Researchers investigated whether the SARS-CoV-2 spike protein could bind to the ACE2 receptors from 22 different animals to ascertain which of these, if any, may be susceptible to infection. More...